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Adenosquamous carcinoma of the lung (view source)
Revision as of 14:48, 6 April 2023
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid25002356>{{Cite journal | last1 = Rao | first1 = N. | title = Adenosquamous carcinoma. | journal = Semin Diagn Pathol | volume = 31 | issue = 4 | pages = 271-7 | month = Jul | year = 2014 | doi = 10.1053/j.semdp.2014.06.004 | PMID = 25002356 }}</ref><ref name=pmid26068980>{{cite journal |authors=Vassella E, Langsch S, Dettmer MS, Schlup C, Neuenschwander M, Frattini M, Gugger M, Schäfer SC |title=Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type? |journal=Oncotarget |volume=6 |issue=27 |pages=23905–16 |date=September 2015 |pmid=26068980 |pmc=4695160 |doi=10.18632/oncotarget.4163 |url=}}</ref> | ||
#Adenocarcinoma component. | #Adenocarcinoma component (>=10% of tumour ‡). | ||
#Squamous cell carcinoma component. | #Squamous cell carcinoma component (>=10% of tumour ‡). | ||
Note: | |||
*‡ Criteria used by individual pathologists may vary and/or may not be uniformly applied.<ref name=pmid25002356>{{Cite journal | last1 = Rao | first1 = N. | title = Adenosquamous carcinoma. | journal = Semin Diagn Pathol | volume = 31 | issue = 4 | pages = 271-7 | month = Jul | year = 2014 | doi = 10.1053/j.semdp.2014.06.004 | PMID = 25002356 }}</ref> | |||
DDx: | |||
*[[Squamous cell carcinoma of the lung]]. | |||
*[[Adenocarcinoma of the lung]]. | |||
*Metastatic [[adenosquamous carcinoma]] - requires history. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: Adenosquamous carcinoma of lung -- intermed mag.jpg | ASC | Image: Adenosquamous carcinoma of lung -- intermed mag.jpg | ASC - intermed. mag. (WC) | ||
Image: Adenosquamous carcinoma of lung - alt -- intermed mag.jpg | ASC | Image: Adenosquamous carcinoma of lung - alt -- intermed mag.jpg | ASC - intermed. mag. (WC) | ||
Image: Adenosquamous carcinoma of lung -- high mag.jpg | ASC | Image: Adenosquamous carcinoma of lung -- high mag.jpg | ASC - high mag. (WC) | ||
Image: Adenosquamous carcinoma of lung -- very high mag.jpg | ASC | Image: Adenosquamous carcinoma of lung -- very high mag.jpg | ASC - very high mag. (WC) | ||
</gallery> | </gallery> | ||
====www==== | ====www==== | ||
*[http://www.webpathology.com/image.asp?case=415&n=21 Lung adenosquamous carcinoma (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=415&n=21 Lung adenosquamous carcinoma (webpathology.com)]. | ||
*[https://www.flickr.com/photos/pulmonary_pathology/7491350926/ Lung adenosquamous carcinoma (flickr.com/Yale Rosen)]. | *[https://www.flickr.com/photos/pulmonary_pathology/7491350926/ Lung adenosquamous carcinoma (flickr.com/Yale Rosen)]. | ||
==Sign out== | |||
===Biopsy - possible adenosquamous carcinoma=== | |||
<pre> | |||
Left Upper Lobe of Lung, Core Biopsy: | |||
- NONSMALL CELL CARCINOMA, FAVOUR ADENOCARCINOMA, CANNOT EXCLUDE ADENOSQUAMOUS CARCINOMA. | |||
Comment: | |||
The tumour stains as follow: | |||
POSITIVE: TTF-1, CK5/6 (focal), p63, napsin A. | |||
NEGATIVE: (none). | |||
The positive staining (TTF-1 and napsin A versus CK5/6 and p63) appears to be in different tumour cells. | |||
The case was reviewed internally and there is agreement on the above interpretation. | |||
</pre> | |||
Note: | |||
*Cases should not be signed as ''adenosquamous carcinoma'' on biopsy, due to the percentage requirements (>=10% for both components) - see ''microscopic'' section. | |||
==See also== | ==See also== | ||