Chronic traumatic encephalopathy: Difference between revisions
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[[Image:Chronic Traumatic Encephalopathy.png|thumb|right|Gross images showing a brain with chronic traumatic encephalopathy (CTE) and a normal brain. (WC/BU)]] | |||
'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases|neurodegenerative disease]] due to repeated trauma. | '''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases|neurodegenerative disease]] due to repeated trauma. | ||
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*Wall-to-wall neurofibrillary tangles. | *Wall-to-wall neurofibrillary tangles. | ||
**Common in olfactory bulb, mammillary bodies, hippocampus. | **Common in olfactory bulb, mammillary bodies, hippocampus. | ||
**Usually perivascular. | **Usually perivascular around small blood vessels. | ||
**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci. | **Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci. | ||
*** But not restricted to superficial regions of sulci (also deep in parenchyma). | |||
**Staging according to Bienik et al.: NFT in <5 regions: low CTE, in 5 or more: high CTE.<ref>{{cite journal |vauthors=Snijders RJ, De Courcy-Wheeler RH, Nicolaides KH |title=Intrauterine growth retardation and fetal transverse cerebellar diameter |journal=Prenat Diagn |volume=14 |issue=12 |pages=1101–5 |date=December 1994 |pmid=7899277 |doi=10.1002/pd.1970141202 |url=}}</ref> | |||
==IHC== | ==IHC== | ||
*Increased TDP-43 staining. | *Increased TDP-43 staining. | ||
*p-Tau neuronal aggregates. | |||
**+/. thron shaped-astrocytes. | |||
*Usu. absence of beta-amyloid. | |||
Note: | Note: | ||
*[[ALS]] associated with | *[[ALS]] associated with traumatic brain injuries.<ref name=pmid21696410>{{Cite journal | last1 = Costanza | first1 = A. | last2 = Weber | first2 = K. | last3 = Gandy | first3 = S. | last4 = Bouras | first4 = C. | last5 = Hof | first5 = PR. | last6 = Giannakopoulos | first6 = P. | last7 = Canuto | first7 = A. | title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. | journal = Neuropathol Appl Neurobiol | volume = 37 | issue = 6 | pages = 570-84 | month = Oct | year = 2011 | doi = 10.1111/j.1365-2990.2011.01186.x | PMID = 21696410 }}</ref> | ||
==See also== | ==See also== | ||