Difference between revisions of "Pyloric gland adenoma"
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| Caption = | | Caption = | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]] | | LMDDx = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]] | ||
| Line 27: | Line 27: | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = other [[GI polyps|polyps]] | ||
| Tx = | | Tx = excision | ||
}} | }} | ||
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | '''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid18830123/> | ||
*Round mildly irregular foveolar-type glands with: | *Round mildly irregular foveolar-type glands with: | ||
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia. | **Nuclei without dysplasia (round and basally located nuclei) or with dysplasia. | ||
| Line 47: | Line 47: | ||
*[[Gastric adenoma]], foveolar-type. | *[[Gastric adenoma]], foveolar-type. | ||
*[[Adenocarcinoma of the stomach]], well-differentiated. | *[[Adenocarcinoma of the stomach]], well-differentiated. | ||
===Images=== | |||
*[http://www.flickriver.com/photos/lunarcaustic/3488308419/ Tubulare adenoma, pyloric gland-type (flickriver.com)]. | |||
==IHC== | ==IHC== | ||
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**Negative in foveolar-type gastric adenomas. | **Negative in foveolar-type gastric adenomas. | ||
*MUC5AC +ve.<ref name=pmid18830123/> | *MUC5AC +ve.<ref name=pmid18830123/> | ||
==See also== | |||
*[[Autoimmune gastritis]]. | |||
==References== | ==References== | ||
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[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||
[[Category:Diagnosis]] | |||
Latest revision as of 17:53, 15 September 2022
| Pyloric gland adenoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia |
| LM DDx | foveolar-type gastric adenoma, well-differentiated gastric adenocarcinoma |
| IHC | MUC6 +ve, MUC5AC +ve, Ki-67 high |
| Site | stomach, duodenum, gallbladder, others |
|
| |
| Associated Dx | well-differentiated gastric adenocarcinoma, autoimmune gastritis |
| Prevalence | uncommon |
| Endoscopy | polyp |
| Prognosis | benign |
| Clin. DDx | other polyps |
| Treatment | excision |
Pyloric gland adenoma, abbreviated PGA, is an uncommon gastrointestinal lesion.
General
- Approximately 3% of gastric polyps.[1]
- Associated with autoimmune gastritis.[2]
- More often seen in women as with autoimmune gastritis.
- Associated with gastric adenocarcinoma.
Microscopic
Features:[3]
- Round mildly irregular foveolar-type glands with:
- Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
- Moderate eosinophilic (or clear) cytoplasm.
DDx:
- Gastric adenoma, foveolar-type.
- Adenocarcinoma of the stomach, well-differentiated.
Images
IHC
See also
References
- ↑ Vieth, M.; Vogel, C.; Kushima, R.; Borchard, F.; Stolte, M. (Jan 2006). "Pyloric gland adenoma-- how to diagnose?". Cesk Patol 42 (1): 4-7. PMID 16506593.
- ↑ Vieth, M.; Montgomery, EA. (Aug 2014). "Some observations on pyloric gland adenoma: an uncommon and long ignored entity!". J Clin Pathol. doi:10.1136/jclinpath-2014-202553. PMID 25092673.
- ↑ 3.0 3.1 3.2 Chen, ZM.; Scudiere, JR.; Abraham, SC.; Montgomery, E. (Feb 2009). "Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.". Am J Surg Pathol 33 (2): 186-93. doi:10.1097/PAS.0b013e31817d7ff4. PMID 18830123.