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Difference between revisions of "Leydig cell tumour"
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| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei | | Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei | ||
| Subtypes = benign (common), malignant (rare) | | Subtypes = benign (common), malignant (rare) | ||
| LMDDx = [[spermatocytic | | LMDDx = [[spermatocytic tumour]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]], [[Leydig cell hyperplasia]] | ||
| Stains = | | Stains = | ||
| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve | | IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve | ||
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DDx: | DDx: | ||
*[[Spermatocytic | *[[Spermatocytic tumour]] (previously ''spermatocytic seminoma'') - may have eosinophilic cytoplasm. | ||
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | *[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | ||
*Leydig cell hyperplasia. | *[[Leydig cell hyperplasia]]. | ||
*[[Granular cell tumour]].<ref name=pmid17284120/> | *[[Granular cell tumour]].<ref name=pmid17284120/> | ||
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**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | **Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | ||
*Vimentin +ve.<ref name=pmid17284120/> | *Vimentin +ve.<ref name=pmid17284120/> | ||
*[[SALL4]] -ve (10 of 10 cases).<ref name=pmid19390421>{{cite journal |authors=Cao D, Li J, Guo CC, Allan RW, Humphrey PA |title=SALL4 is a novel diagnostic marker for testicular germ cell tumors |journal=Am J Surg Pathol |volume=33 |issue=7 |pages=1065–77 |date=July 2009 |pmid=19390421 |doi=10.1097/PAS.0b013e3181a13eef |url=}}</ref> | |||
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