Difference between revisions of "Psammoma bodies"

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[[Image:Psammomatous melanotic schwannoma - very high mag.jpg|200px|thumb|Psammoma body. [[H&E stain]].]]
[[Image:Serous carcinoma - omentum -- very high mag.jpg|300px|thumb|Psammoma bodies in [[serous carcinoma]]. [[H&E stain]].]]
'''Psammoma bodies''' appear in benign and malignant conditions.  Their presence can help focus the DDx.<ref>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref>
[[Image:Meningioma showing Psammoma body.jpg|300px|thumb|Psammoma bodies in [[meningioma]]. [[H&E stain]].]]
'''Psammoma bodies''' appear in benign and malignant conditions.  Their presence can help focus the DDx.<ref>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref>  
 
They are often associated with a papillary architecture.{{fact}}


==Conditions with psammoma bodies==
==Conditions with psammoma bodies==
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===Benign===
===Benign===
*[[Endosalpingiosis]].
*[[Endosalpingiosis]].
*Intrauterine device (IUD).<ref name=pmid12278909>{{Cite journal  | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi =  | PMID = 12278909 }}</ref>
*[[Endometriosis]].<ref name=pmid8725135>{{Cite journal  | last1 = Minkowitz | first1 = G. | title = Psammoma bodies in endometriosis: clinical, cytological, and physiopathological implications. | journal = Diagn Cytopathol | volume = 14 | issue = 4 | pages = 331-3 | month = Jun | year = 1996 | doi = 10.1002/(SICI)1097-0339(199605)14:4<331::AID-DC11>3.0.CO;2-L | PMID = 8725135 }}</ref><ref name=pmid15098252>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 }}</ref>
*[[Intrauterine device]] (IUD).<ref name=pmid12278909>{{Cite journal  | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi =  | PMID = 12278909 }}</ref>
*[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref>
*[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref>
*[[Meningioma]]. <ref>{{Cite journal  | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue =  | pages = 255-62 | month = Apr | year = 1961 | doi =  | PMID = 13752577 }}</ref>
*[[Pituitary adenoma]]. <ref>{{Cite journal  | last1 = Wolfson | first1 = WL. | last2 = Rosenthal | first2 = DL. | last3 = Harney | first3 = B. | title = Psammoma bodies in pituitary adenoma. | journal = Acta Cytol | volume = 23 | issue = 1 | pages = 90-2 | month =  | year =  | doi =  | PMID = 285558 }}</ref>
*[[Choroid plexus papilloma]]. <ref>{{Cite journal  | last1 = Jovanović | first1 = I. | last2 = Ugrenović | first2 = S. | last3 = Vasović | first3 = L. | last4 = Petrović | first4 = D. | last5 = Cekić | first5 = S. | title = Psammoma bodies - friends or foes of the aging choroid plexus. | journal = Med Hypotheses | volume = 74 | issue = 6 | pages = 1017-20 | month = Jun | year = 2010 | doi = 10.1016/j.mehy.2010.01.006 | PMID = 20116930 }}</ref>


===Malignant===
===Malignant===
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*[[Somatostatinoma]], [[duodenum|duodenal]].<ref name=pmid21437171>{{Cite journal  | last1 = Kim | first1 = JA. | last2 = Choi | first2 = WH. | last3 = Kim | first3 = CN. | last4 = Moon | first4 = YS. | last5 = Chang | first5 = SH. | last6 = Lee | first6 = HR. | title = Duodenal somatostatinoma: a case report and review. | journal = Korean J Intern Med | volume = 26 | issue = 1 | pages = 103-7 | month = Mar | year = 2011 | doi = 10.3904/kjim.2011.26.1.103 | PMID = 21437171 }}</ref>  
*[[Somatostatinoma]], [[duodenum|duodenal]].<ref name=pmid21437171>{{Cite journal  | last1 = Kim | first1 = JA. | last2 = Choi | first2 = WH. | last3 = Kim | first3 = CN. | last4 = Moon | first4 = YS. | last5 = Chang | first5 = SH. | last6 = Lee | first6 = HR. | title = Duodenal somatostatinoma: a case report and review. | journal = Korean J Intern Med | volume = 26 | issue = 1 | pages = 103-7 | month = Mar | year = 2011 | doi = 10.3904/kjim.2011.26.1.103 | PMID = 21437171 }}</ref>  
*[[Papillary renal cell carcinoma]].
*[[Papillary renal cell carcinoma]].
*[[Meningioma]].
*Anaplastic [[Meningioma]].<ref>{{Cite journal  | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue =  | pages = 255-62 | month = Apr | year = 1961 | doi =  | PMID = 13752577 }}</ref>
*[[Mesothelioma]].
*[[Mesothelioma]].
*[[Biphasic hyalinizing psammomatous renal cell carcinoma]].
Memory device for common tumours ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref>


Memory device ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref>
Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. <ref>{{Cite journal  | last1 = Ellison | first1 = E. | last2 = Lapuerta | first2 = P. | last3 = Martin | first3 = SE. | title = Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma. | journal = Cancer | volume = 84 | issue = 3 | pages = 169-75 | month = Jun | year = 1998 | doi =  | PMID = 9678732 }}</ref>


==See also==
==See also==
*[[Endometrium with psammoma bodies]].
*[[Endometrium with psammoma bodies]].
*[[Calcifications]].


==References==
==References==

Latest revision as of 05:14, 13 October 2021

Psammoma bodies in serous carcinoma. H&E stain.
Psammoma bodies in meningioma. H&E stain.

Psammoma bodies appear in benign and malignant conditions. Their presence can help focus the DDx.[1]

They are often associated with a papillary architecture.[citation needed]

Conditions with psammoma bodies

The following is an incomplete list.

Benign

Malignant

Memory device for common tumours PSaMMoma: Papillary (thyroid, renal), Serous (ovary), Meningioma, Mesothelioma.[11]

Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. [12]

See also

References

  1. ↑ Parwani, AV.; Chan, TY.; Ali, SZ. (Apr 2004). "Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis.". Cancer 102 (2): 87-91. doi:10.1002/cncr.20161. PMID 15098252.
  2. ↑ Minkowitz, G. (Jun 1996). "Psammoma bodies in endometriosis: clinical, cytological, and physiopathological implications.". Diagn Cytopathol 14 (4): 331-3. doi:10.1002/(SICI)1097-0339(199605)14:4<331::AID-DC11>3.0.CO;2-L. PMID 8725135.
  3. ↑ Parwani, AV.; Chan, TY.; Ali, SZ. (Apr 2004). "Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis.". Cancer 102 (2): 87-91. doi:10.1002/cncr.20161. PMID 15098252.
  4. ↑ Boon, ME.; Kirk, RS.; De Graaff Guilloud, JC. (Jul 1981). "Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD.". Contracept Deliv Syst 2 (3): 231-6. PMID 12278909.
  5. ↑ Fausett MB, Zahn CM, Kendall BS, Barth WH (February 2002). "The significance of psammoma bodies that are found incidentally during endometrial biopsy". Am. J. Obstet. Gynecol. 186 (2): 180–3. PMID 11854631.
  6. ↑ KEPES, J. (Apr 1961). "Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas.". J Neuropathol Exp Neurol 20: 255-62. PMID 13752577.
  7. ↑ Wolfson, WL.; Rosenthal, DL.; Harney, B.. "Psammoma bodies in pituitary adenoma.". Acta Cytol 23 (1): 90-2. PMID 285558.
  8. ↑ Jovanović, I.; Ugrenović, S.; Vasović, L.; Petrović, D.; Cekić, S. (Jun 2010). "Psammoma bodies - friends or foes of the aging choroid plexus.". Med Hypotheses 74 (6): 1017-20. doi:10.1016/j.mehy.2010.01.006. PMID 20116930.
  9. ↑ Kim, JA.; Choi, WH.; Kim, CN.; Moon, YS.; Chang, SH.; Lee, HR. (Mar 2011). "Duodenal somatostatinoma: a case report and review.". Korean J Intern Med 26 (1): 103-7. doi:10.3904/kjim.2011.26.1.103. PMID 21437171.
  10. ↑ KEPES, J. (Apr 1961). "Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas.". J Neuropathol Exp Neurol 20: 255-62. PMID 13752577.
  11. ↑ URL: http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html. Accessed on: 15 January 2012.
  12. ↑ Ellison, E.; Lapuerta, P.; Martin, SE. (Jun 1998). "Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma.". Cancer 84 (3): 169-75. PMID 9678732.
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