Hairy cell leukemia: Difference between revisions
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*Good prognosis (with treatment), though (likely) not curable. | *Good prognosis (with treatment), though (likely) not curable. | ||
==Gross== | |||
Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8|326}}</ref> | Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8|326}}</ref> | ||
*Huge beefy red [[spleen]]. | *Huge beefy red [[spleen]]. | ||
**Red as white pulp obliterated. | **Red as white pulp obliterated. | ||
==Microscopic== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref> | Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref> | ||
*Small cells (10-20 micrometers) with "Fried egg"-like appearance: | *Small cells (10-20 micrometers) with "Fried egg"-like appearance: | ||
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*[[Hepatosplenic T-cell lymphoma]]. | *[[Hepatosplenic T-cell lymphoma]]. | ||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Hairy_cell_leukemia.jpg | HCL - blood film. (WC) | Image:Hairy_cell_leukemia.jpg | HCL - blood film. (WC) | ||
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*[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)]. | *[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)]. | ||
==IHC== | |||
Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref> | Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref> | ||
*CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve | *CD20 +ve, CD11c+ve, CD25 +ve, CD103 +ve, CD123 +ve, cyclin D1 +ve, DBA44 +ve | ||
*Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells) | *Annexin A1 +ve (only useful in heavy bone marrow infiltration as it is also positive in T-cells and granulopoietic cells) | ||
*TRAP - tartrate-resistant acid phosphatase (historically histochemically, now immunohistochemically) | |||
*[[HBME1]]<ref name=pmid24092261>{{cite journal |authors=Krenács L, Tóth-Lipták J, Demeter J, Piukovics K, Borbényi Z, Gogolák P, Sári E, Bagdi E |title=Monoclonal antibody HBME-1 reacts with a minor subset of B cells with villous surface and can be useful in the diagnosis of hairy cell leukemia and other indolent lymphoproliferations of villous B lymphocytes |journal=Virchows Arch. |volume=463 |issue=6 |pages=787–94 |date=December 2013 |pmid=24092261 |doi=10.1007/s00428-013-1490-5 |url=}}</ref> | |||
*BRAF V600E mutation-specific antibody | *BRAF V600E mutation-specific antibody | ||
*CD5 -ve. | *CD5 -ve. | ||
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*CD19 +ve, CD11c +ve, FMC7 +ve. | *CD19 +ve, CD11c +ve, FMC7 +ve. | ||
===References | ==See also== | ||
*[[Small cell lymphomas]]. | |||
==References== | |||
{{Reflist}} | {{Reflist}} | ||
[[Category: Haematopathology]] | [[Category: Haematopathology]] | ||