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Difference between revisions of "Cribriform adenocarcinoma of the minor salivary gland"
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Cribriform adenocarcinoma of the minor salivary gland (view source)
Revision as of 20:23, 25 February 2021
, 20:23, 25 February 2021→Referencess
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]]. | ||
| Synonyms = cribriform | | Synonyms = cribriform adenocarcinoma of the tongue | ||
| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium | | Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium | ||
| Subtypes = | | Subtypes = | ||
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'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/> | '''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/> | ||
It is also known as '''cribriform | It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''. | ||
The ''World Health Organization'' lumps this tumour with [[polymorphous adenocarcinoma]], a decision that is considered "controversial".<ref name=pmid29761209>{{cite journal |authors=Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A |title=Polymorphous adenocarcinoma of the salivary glands: reappraisal and update |journal=Eur Arch Otorhinolaryngol |volume=275 |issue=7 |pages=1681–1695 |date=July 2018 |pmid=29761209 |doi=10.1007/s00405-018-4985-5 |url=}}</ref> | |||
==General== | ==General== | ||
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Features: | Features: | ||
*Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref> | *Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref> | ||
*Growth patterns - cribriform and solid. | *Growth patterns - [[cribriform]] and solid. | ||
*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/> | *Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/> | ||
**Irregular nuclear membranes (raisin-like nuclei). | **Irregular nuclear membranes (raisin-like nuclei). | ||
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DDx: | DDx: | ||
*[[Polymorphous low grade adenocarcinoma | *[[Polymorphous adenocarcinoma]] (previously polymorphous low-grade adenocarcinoma) - morphology more varied. | ||
*[[Papillary thyroid carcinoma]]. | *[[Papillary thyroid carcinoma]]. | ||
===Images=== | ===Images=== | ||
www | <gallery> | ||
Image: Cribriform adenocarcinoma of the tongue -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- very high mag.jpg | CAT - very high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1b -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- very high mag.jpg | CAT - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | ||
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*Vimentin +ve (12/12 cases). | *Vimentin +ve (12/12 cases). | ||
*CD117 -ve/+ve (5+ve/12 cases). | *CD117 -ve/+ve (5+ve/12 cases). | ||
==Molecular== | |||
*Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).<ref name=pmid24942367>{{Cite journal | last1 = Weinreb | first1 = I. | last2 = Zhang | first2 = L. | last3 = Tirunagari | first3 = LM. | last4 = Sung | first4 = YS. | last5 = Chen | first5 = CL. | last6 = Perez-Ordonez | first6 = B. | last7 = Clarke | first7 = BA. | last8 = Skalova | first8 = A. | last9 = Chiosea | first9 = SI. | title = Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. | journal = Genes Chromosomes Cancer | volume = 53 | issue = 10 | pages = 845-56 | month = Oct | year = 2014 | doi = 10.1002/gcc.22195 | PMID = 24942367 }}</ref> | |||
==See also== | ==See also== | ||
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==Referencess== | ==Referencess== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | [[Category:Salivary gland]] | ||