Difference between revisions of "Cribriform adenocarcinoma of the minor salivary gland"
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'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | |||
| Width = | |||
| Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]]. | |||
| Synonyms = cribriform adenocarcinoma of the tongue | |||
| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium | |||
| Subtypes = | |||
| LMDDx = [[polymorphous low grade adenocarcinoma]], [[papillary thyroid carcinoma]] | |||
| Stains = | |||
| IHC = CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[head and neck pathology|head and neck]] - usually [[tongue]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = other [[salivary gland]] tumours | |||
| Tx = excision | |||
}} | |||
'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/> | |||
It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''. | |||
The ''World Health Organization'' lumps this tumour with [[polymorphous adenocarcinoma]], a decision that is considered "controversial".<ref name=pmid29761209>{{cite journal |authors=Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A |title=Polymorphous adenocarcinoma of the salivary glands: reappraisal and update |journal=Eur Arch Otorhinolaryngol |volume=275 |issue=7 |pages=1681–1695 |date=July 2018 |pmid=29761209 |doi=10.1007/s00405-018-4985-5 |url=}}</ref> | |||
==General== | ==General== | ||
*Rare. | *Rare - small case series and case reports. | ||
*Typically tongue - first described there.<ref name=pmid10583573 | *Typically [[tongue]] - first described there.<ref name=pmid10583573>{{Cite journal | last1 = Michal | first1 = M. | last2 = Skálová | first2 = A. | last3 = Simpson | first3 = RH. | last4 = Raslan | first4 = WF. | last5 = Curík | first5 = R. | last6 = Leivo | first6 = I. | last7 = Mukensnábl | first7 = P. | title = Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. | journal = Histopathology | volume = 35 | issue = 6 | pages = 495-501 | month = Dec | year = 1999 | doi = | PMID = 10583573 }}</ref> | ||
*Good prognosis<ref name=pmid21716087/> - on limited data. | *Good prognosis<ref name=pmid21716087/> - on limited data. | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Typically covered by intact squamous epithelium.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref> | *Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref> | ||
*Growth patterns - cribriform and solid. | *Growth patterns - [[cribriform]] and solid. | ||
*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/> | *Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/> | ||
**Irregular nuclear membranes (raisin-like nuclei). | |||
**Nuclear overlap. | |||
DDx: | DDx: | ||
*[[Polymorphous low grade adenocarcinoma | *[[Polymorphous adenocarcinoma]] (previously polymorphous low-grade adenocarcinoma) - morphology more varied. | ||
*[[Papillary thyroid carcinoma]]. | *[[Papillary thyroid carcinoma]]. | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Cribriform adenocarcinoma of the tongue -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- very high mag.jpg | CAT - very high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1b -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- very high mag.jpg | CAT - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | ||
==IHC== | |||
Features:<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref> | |||
*AE1/AE3 +ve (12/12 cases). | |||
*CAM5.2 +ve (12/12 cases). | |||
*CK7 +ve (12/12 cases). | |||
*CK8 +ve (12/12 cases). | |||
*CK18 +ve (12/12 cases). | |||
*S-100 +ve (12/12 cases). | |||
*Vimentin +ve (12/12 cases). | |||
*CD117 -ve/+ve (5+ve/12 cases). | |||
==Molecular== | |||
*Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).<ref name=pmid24942367>{{Cite journal | last1 = Weinreb | first1 = I. | last2 = Zhang | first2 = L. | last3 = Tirunagari | first3 = LM. | last4 = Sung | first4 = YS. | last5 = Chen | first5 = CL. | last6 = Perez-Ordonez | first6 = B. | last7 = Clarke | first7 = BA. | last8 = Skalova | first8 = A. | last9 = Chiosea | first9 = SI. | title = Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. | journal = Genes Chromosomes Cancer | volume = 53 | issue = 10 | pages = 845-56 | month = Oct | year = 2014 | doi = 10.1002/gcc.22195 | PMID = 24942367 }}</ref> | |||
==See also== | ==See also== | ||
| Line 24: | Line 90: | ||
==Referencess== | ==Referencess== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | [[Category:Salivary gland]] | ||
Latest revision as of 20:23, 25 February 2021
| Cribriform adenocarcinoma of the minor salivary gland | |
|---|---|
| Diagnosis in short | |
 Cribriform adenocarcinoma of the minor salivary gland. H&E stain. | |
|
| |
| Synonyms | cribriform adenocarcinoma of the tongue |
|
| |
| LM | cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium |
| LM DDx | polymorphous low grade adenocarcinoma, papillary thyroid carcinoma |
| IHC | CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve |
| Site | head and neck - usually tongue |
|
| |
| Prevalence | very rare |
| Prognosis | good |
| Clin. DDx | other salivary gland tumours |
| Treatment | excision |
Cribriform adenocarcinoma of the minor salivary gland, abbreviated CAMSG, is a rare malignancy of the salivary gland, typically of the tongue.[1]
It is also known as cribriform adenocarcinoma of the tongue, abbreviated CAT.
The World Health Organization lumps this tumour with polymorphous adenocarcinoma, a decision that is considered "controversial".[2]
General
- Rare - small case series and case reports.
- Typically tongue - first described there.[3]
- Good prognosis[1] - on limited data.
Microscopic
Features:
- Typically covered by an intact squamous epithelium.[1]
- Growth patterns - cribriform and solid.
- Cytology similar to papillary thyroid carcinoma.[1]
- Irregular nuclear membranes (raisin-like nuclei).
- Nuclear overlap.
DDx:
- Polymorphous adenocarcinoma (previously polymorphous low-grade adenocarcinoma) - morphology more varied.
- Papillary thyroid carcinoma.
Images
CAT - low mag.
CAT - intermed. mag.
CAT - high mag.
CAT - very high mag.
CAT - low mag.
CAT - intermed. mag.
CAT - intermed. mag.
CAT - intermed. mag.
CAT - high mag.
CAT - very high mag.
www
IHC
Features:[1]
- AE1/AE3 +ve (12/12 cases).
- CAM5.2 +ve (12/12 cases).
- CK7 +ve (12/12 cases).
- CK8 +ve (12/12 cases).
- CK18 +ve (12/12 cases).
- S-100 +ve (12/12 cases).
- Vimentin +ve (12/12 cases).
- CD117 -ve/+ve (5+ve/12 cases).
Molecular
- Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).[5]
See also
Referencess
- ↑ 1.0 1.1 1.2 1.3 1.4 Skalova, A.; Sima, R.; Kaspirkova-Nemcova, J.; Simpson, RH.; Elmberger, G.; Leivo, I.; Di Palma, S.; Jirasek, T. et al. (Aug 2011). "Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity.". Am J Surg Pathol 35 (8): 1168-76. doi:10.1097/PAS.0b013e31821e1f54. PMID 21716087.
- ↑ Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A (July 2018). "Polymorphous adenocarcinoma of the salivary glands: reappraisal and update". Eur Arch Otorhinolaryngol 275 (7): 1681–1695. doi:10.1007/s00405-018-4985-5. PMID 29761209.
- ↑ Michal, M.; Skálová, A.; Simpson, RH.; Raslan, WF.; Curík, R.; Leivo, I.; Mukensnábl, P. (Dec 1999). "Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue.". Histopathology 35 (6): 495-501. PMID 10583573.
- ↑ 4.0 4.1 Michal, M.; Kacerovska, D.; Kazakov, DV. (Jul 2013). "Cribriform adenocarcinoma of the tongue and minor salivary glands: a review.". Head Neck Pathol 7 Suppl 1: S3-11. doi:10.1007/s12105-013-0457-9. PMID 23821209.
- ↑ Weinreb, I.; Zhang, L.; Tirunagari, LM.; Sung, YS.; Chen, CL.; Perez-Ordonez, B.; Clarke, BA.; Skalova, A. et al. (Oct 2014). "Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.". Genes Chromosomes Cancer 53 (10): 845-56. doi:10.1002/gcc.22195. PMID 24942367.