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'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg
| Width      =
| Caption    = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]].
| Synonyms  = cribriform adenocarcinoma of the tongue
| Micro      = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium
| Subtypes  =
| LMDDx      = [[polymorphous low grade adenocarcinoma]], [[papillary thyroid carcinoma]]
| Stains    =
| IHC        = CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[head and neck pathology|head and neck]] - usually [[tongue]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    = other [[salivary gland]] tumours
| Tx        = excision
}}
'''Cribriform adenocarcinoma of the minor salivary gland''', abbreviated '''CAMSG''', is a rare [[malignancy]] of the [[salivary gland]], typically of the [[tongue]].<ref name=pmid21716087/>
 
It is also known as '''cribriform adenocarcinoma of the tongue''', abbreviated '''CAT'''.
 
The ''World Health Organization'' lumps this tumour with [[polymorphous adenocarcinoma]], a decision that is considered "controversial".<ref name=pmid29761209>{{cite journal |authors=Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A |title=Polymorphous adenocarcinoma of the salivary glands: reappraisal and update |journal=Eur Arch Otorhinolaryngol |volume=275 |issue=7 |pages=1681–1695 |date=July 2018 |pmid=29761209 |doi=10.1007/s00405-018-4985-5 |url=}}</ref>


==General==
==General==
*Rare.
*Rare - small case series and case reports.
*Base of tongue.
*Typically [[tongue]] - first described there.<ref name=pmid10583573>{{Cite journal  | last1 = Michal | first1 = M. | last2 = Skálová | first2 = A. | last3 = Simpson | first3 = RH. | last4 = Raslan | first4 = WF. | last5 = Curík | first5 = R. | last6 = Leivo | first6 = I. | last7 = Mukensnábl | first7 = P. | title = Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. | journal = Histopathology | volume = 35 | issue = 6 | pages = 495-501 | month = Dec | year = 1999 | doi =  | PMID = 10583573 }}</ref>
*Good prognosis<ref name=pmid21716087/> - on limited data.


==Microscopic==
==Microscopic==
Features:
Features:
*Typically covered by intact squamous epithelium.<ref name=pmid21716087>{{Cite journal  | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref>
*Typically covered by an intact squamous epithelium.<ref name=pmid21716087>{{Cite journal  | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref>
*Growth patterns - cribriform and solid.
*Growth patterns - [[cribriform]] and solid.
*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>
*Cytology similar to [[papillary thyroid carcinoma]].<ref name=pmid21716087/>
**Irregular nuclear membranes (raisin-like nuclei).
**Nuclear overlap.
DDx:
*[[Polymorphous adenocarcinoma]] (previously polymorphous low-grade adenocarcinoma) - morphology more varied.
*[[Papillary thyroid carcinoma]].


===Images===
===Images===
<gallery>
Image: Cribriform adenocarcinoma of the tongue -- low mag.jpg | CAT - low mag.
Image: Cribriform adenocarcinoma of the tongue -- intermed mag.jpg | CAT - intermed. mag.
Image: Cribriform adenocarcinoma of the tongue -- high mag.jpg | CAT - high mag.
Image: Cribriform adenocarcinoma of the tongue -- very high mag.jpg | CAT - very high mag.
Image: Cribriform adenocarcinoma of the tongue - a1 -- low mag.jpg | CAT - low mag.
Image: Cribriform adenocarcinoma of the tongue - a1 -- intermed mag.jpg | CAT - intermed. mag.
Image: Cribriform adenocarcinoma of the tongue - a1b -- intermed mag.jpg | CAT - intermed. mag.
Image: Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | CAT - intermed. mag.
Image: Cribriform adenocarcinoma of the tongue - a2 -- high mag.jpg | CAT - high mag.
Image: Cribriform adenocarcinoma of the tongue - a2 -- very high mag.jpg | CAT - very high mag.
</gallery>
====www====
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/  CAMSG (nih.gov)].<ref name=pmid23821209/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/  CAMSG (nih.gov)].<ref name=pmid23821209/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal  | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue =  | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal  | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue =  | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref>
==IHC==
Features:<ref name=pmid21716087>{{Cite journal  | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }}</ref>
*AE1/AE3 +ve (12/12 cases).
*CAM5.2 +ve (12/12 cases).
*CK7 +ve (12/12 cases).
*CK8 +ve (12/12 cases).
*CK18 +ve (12/12 cases).
*S-100 +ve (12/12 cases).
*Vimentin +ve (12/12 cases).
*CD117 -ve/+ve (5+ve/12 cases).
==Molecular==
*Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).<ref name=pmid24942367>{{Cite journal  | last1 = Weinreb | first1 = I. | last2 = Zhang | first2 = L. | last3 = Tirunagari | first3 = LM. | last4 = Sung | first4 = YS. | last5 = Chen | first5 = CL. | last6 = Perez-Ordonez | first6 = B. | last7 = Clarke | first7 = BA. | last8 = Skalova | first8 = A. | last9 = Chiosea | first9 = SI. | title = Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. | journal = Genes Chromosomes Cancer | volume = 53 | issue = 10 | pages = 845-56 | month = Oct | year = 2014 | doi = 10.1002/gcc.22195 | PMID = 24942367 }}</ref>


==See also==
==See also==
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==Referencess==
==Referencess==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]
[[Category:Salivary gland]]
Michael
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