Difference between revisions of "Ovarian microcystic stromal tumour"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Microcystic stromal tumour of ovary -- intermed mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Microcystic stromal tumour of ovary. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      =
| Micro      = microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma
| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      = other [[sex cord stromal tumours]]
| Stains    =
| Stains    =
| IHC        =
| IHC        = CD10 +ve (cytoplasmic), beta-catenin (nuclear) +ve, WT-1 +ve, cyclin D1 +ve, inhibin -ve, calretinin -ve, ER-, PR-
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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| Prognosis  = unknown
| Prognosis  = unknown
| Other      =
| Other      =
| ClinDDx    = other [[ovarian tumours]], [[testis|testicular tumours]]
| ClinDDx    = other [[ovarian tumours]], other [[testis|testicular tumours]]
| Tx        = excision
| Tx        = excision
}}
}}
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*Evolving entity.
*Evolving entity.
*Reported in the testis.<ref name=pmid29169232>{{Cite journal  | last1 = Zhu | first1 = P. | last2 = Duan | first2 = Y. | last3 = Ao | first3 = Q. | last4 = Wang | first4 = G. | title = Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. | journal = Cancer Res Treat | volume = 50 | issue = 4 | pages = 1452-1457 | month = Oct | year = 2018 | doi = 10.4143/crt.2017.414 | PMID = 29169232 }}</ref>
*Reported in the testis.<ref name=pmid29169232>{{Cite journal  | last1 = Zhu | first1 = P. | last2 = Duan | first2 = Y. | last3 = Ao | first3 = Q. | last4 = Wang | first4 = G. | title = Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. | journal = Cancer Res Treat | volume = 50 | issue = 4 | pages = 1452-1457 | month = Oct | year = 2018 | doi = 10.4143/crt.2017.414 | PMID = 29169232 }}</ref>
*[[Sex cord stromal tumour]].<ref name=pmid26200099>{{Cite journal  | last1 = Irving | first1 = JA. | last2 = Lee | first2 = CH. | last3 = Yip | first3 = S. | last4 = Oliva | first4 = E. | last5 = McCluggage | first5 = WG. | last6 = Young | first6 = RH. | title = Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations. | journal = Am J Surg Pathol | volume = 39 | issue = 10 | pages = 1420-6 | month = Oct | year = 2015 | doi = 10.1097/PAS.0000000000000482 | PMID = 26200099 }}</ref><ref name=pmid30014019>{{Cite journal  | last1 = Jeong | first1 = D. | last2 = Hakam | first2 = A. | last3 = Abuel-Haija | first3 = M. | last4 = Chon | first4 = HS. | title = Ovarian microcystic stromal tumor: Radiologic-pathologic correlation. | journal = Gynecol Oncol Rep | volume = 25 | issue =  | pages = 11-14 | month = Aug | year = 2018 | doi = 10.1016/j.gore.2018.05.004 | PMID = 30014019 }}</ref>


==Microscopic==
==Microscopic==
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*Microcysts alternating with solid cellular regions.
*Microcysts alternating with solid cellular regions.
*Hyalinized fibrous stroma.
*Hyalinized fibrous stroma.
DDx:
*Other [[sex cord stromal tumours]].


===Images===
===Images===

Latest revision as of 14:30, 16 October 2019

Ovarian microcystic stromal tumour
Diagnosis in short

Microcystic stromal tumour of ovary. H&E stain.
LM microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma
LM DDx other sex cord stromal tumours
IHC CD10 +ve (cytoplasmic), beta-catenin (nuclear) +ve, WT-1 +ve, cyclin D1 +ve, inhibin -ve, calretinin -ve, ER-, PR-
Site ovary, testis
Prevalence rare, evolving entity
Prognosis unknown
Clin. DDx other ovarian tumours, other testicular tumours
Treatment excision

Ovarian microcystic stromal tumour (abbreviated MST), also microcystic stromal tumour of the ovary, is a rare ovarian tumour.

General

Microscopic

Features:[4]

  • Microcysts alternating with solid cellular regions.
  • Hyalinized fibrous stroma.

DDx:

Images

  • MST - extremely low mag. (WC)

  • MST - very low mag. (WC)

  • MST - low mag. (WC)

  • MST - intermed. mag. (WC)

  • MST - high mag. (WC)

  • MST - high mag. (WC)

  • MST - very high mag. (WC)

IHC

Features:[4]

  • CD10 +ve (cytoplasmic).
  • Beta-catenin +ve (nuclear).
  • WT1 +ve.
  • Cyclin D1 +ve.
  • Inhibin -ve.
  • Calretinin -ve.
  • ER -ve.
  • PR -ve.

Molecular

  • CTNNB1 mutation.[5]

References

  1. ↑ Zhu, P.; Duan, Y.; Ao, Q.; Wang, G. (Oct 2018). "Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.". Cancer Res Treat 50 (4): 1452-1457. doi:10.4143/crt.2017.414. PMID 29169232.
  2. ↑ Irving, JA.; Lee, CH.; Yip, S.; Oliva, E.; McCluggage, WG.; Young, RH. (Oct 2015). "Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations.". Am J Surg Pathol 39 (10): 1420-6. doi:10.1097/PAS.0000000000000482. PMID 26200099.
  3. ↑ Jeong, D.; Hakam, A.; Abuel-Haija, M.; Chon, HS. (Aug 2018). "Ovarian microcystic stromal tumor: Radiologic-pathologic correlation.". Gynecol Oncol Rep 25: 11-14. doi:10.1016/j.gore.2018.05.004. PMID 30014019.
  4. ↑ 4.0 4.1 McCluggage, WG.; Chong, AS.; Attygalle, AD.; Clarke, BA.; Chapman, W.; Rivera, B.; Foulkes, WD. (Feb 2019). "Expanding the morphological spectrum of ovarian microcystic stromal tumour.". Histopathology 74 (3): 443-451. doi:10.1111/his.13755. PMID 30325056.
  5. ↑ Na, K.; Kim, EK.; Jang, W.; Kim, HS. (Jun 2017). "CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation.". Anticancer Res 37 (6): 3249-3258. doi:10.21873/anticanres.11688. PMID 28551672.
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