Difference between revisions of "Malignant histiocytosis"
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'''Histiocytic sarcoma''' is a rare tumour. | '''Malignant histiocytosis''' is a rare malignant type of [[histiocytosis]]. | ||
'''Histiocytic sarcoma''' is considered by many as a synonym;<ref>{{Cite journal | last1 = Low | first1 = SE. | last2 = Stafford | first2 = JS. | title = Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture. | journal = J Clin Pathol | volume = 59 | issue = 7 | pages = 770-2 | month = Jul | year = 2006 | doi = 10.1136/jcp.2005.027870 | PMID = 16803951 }}</ref> it redirects to this article. | |||
==General== | ==General== | ||
| Line 5: | Line 7: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 }}</ref> | Features:<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | PMC = 1808440 | URL = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | ||
*Malignant histiocyte-like cells: | *Malignant histiocyte-like cells: | ||
**Nuclear atypia. | **Nuclear atypia. | ||
| Line 16: | Line 18: | ||
Image: | Image: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F2/ HS (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F2/ HS (nih.gov)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F3/ HS (nih.gov)]. | |||
==IHC== | ==IHC== | ||
Features:<ref name=pmid17324277> | Features:<ref name=pmid17324277/> | ||
*CD68 +ve. | *CD68 +ve. | ||
==See also== | ==See also== | ||
*[[Histiocytoses]]. | *[[Histiocytoses]]. | ||
*[[Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages]]. | |||
*[[Sarcoma]]. | *[[Sarcoma]]. | ||
Latest revision as of 19:29, 23 July 2019
Malignant histiocytosis is a rare malignant type of histiocytosis.
Histiocytic sarcoma is considered by many as a synonym;[1] it redirects to this article.
General
- Uncommon.
Microscopic
Features:[2]
- Malignant histiocyte-like cells:
- Nuclear atypia.
- Abundant eosinophilic cytoplasm.
DDx:
- Pleomorphic undifferentiated sarcoma.
- Poorly differentiated carcinoma.
Image:
IHC
Features:[2]
- CD68 +ve.
See also
- Histiocytoses.
- Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.
- Sarcoma.
References
- ↑ Low, SE.; Stafford, JS. (Jul 2006). "Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture.". J Clin Pathol 59 (7): 770-2. doi:10.1136/jcp.2005.027870. PMID 16803951.
- ↑ 2.0 2.1 Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMC 1808440. PMID 17324277. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/.