Smoking-related interstitial fibrosis: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
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| Synonyms = | |||
| Micro = septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation | |||
| Subtypes = | |||
| LMDDx = [[usual interstitial pneumonia]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = subpleural and centrilobular predominance | |||
| Grossing = | |||
| Staging = | |||
| Site = [[lung]] | |||
| Assdx = [[emphysema]], respiratory bronchiolitis | |||
| Syndromes = | |||
| Clinicalhx = [[smoking]] | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign, better than UIP | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]]. | '''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]]. | ||
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Clinical: | Clinical: | ||
*Much better prognosis than UIP with emphysema - five year survival 86% (SRIF) versus 41% (UIP).<ref name=pmid27611866>{{Cite journal | last1 = Chae | first1 = KJ. | last2 = Jin | first2 = GY. | last3 = Jung | first3 = HN. | last4 = Kwon | first4 = KS. | last5 = Choi | first5 = H. | last6 = Lee | first6 = YC. | last7 = Chung | first7 = MJ. | last8 = Park | first8 = HS. | title = Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. | journal = PLoS One | volume = 11 | issue = 9 | pages = e0162231 | month = | year = 2016 | doi = 10.1371/journal.pone.0162231 | PMID = 27611866 }}</ref> | *Much better prognosis than [[usual interstitial pneumonia]] (UIP) with [[emphysema]] - five year survival 86% (SRIF) versus 41% (UIP).<ref name=pmid27611866>{{Cite journal | last1 = Chae | first1 = KJ. | last2 = Jin | first2 = GY. | last3 = Jung | first3 = HN. | last4 = Kwon | first4 = KS. | last5 = Choi | first5 = H. | last6 = Lee | first6 = YC. | last7 = Chung | first7 = MJ. | last8 = Park | first8 = HS. | title = Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. | journal = PLoS One | volume = 11 | issue = 9 | pages = e0162231 | month = | year = 2016 | doi = 10.1371/journal.pone.0162231 | PMID = 27611866 }}</ref> | ||
==Gross== | ==Gross== | ||
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*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017577/figure/pone.0162231.g007/ SRIF (nih.gov)].<ref name=pmid27611866/> | *[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017577/figure/pone.0162231.g007/ SRIF (nih.gov)].<ref name=pmid27611866/> | ||
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428/figure/f1-copd-9-525/ SRIF (nih.gov)].<ref name=pmid24920890>{{Cite journal | last1 = Primiani | first1 = A. | last2 = Dias-Santagata | first2 = D. | last3 = Iafrate | first3 = AJ. | last4 = Kradin | first4 = RL. | title = Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. | journal = Int J Chron Obstruct Pulmon Dis | volume = 9 | issue = | pages = 525-31 | month = | year = 2014 | doi = 10.2147/COPD.S61932 | PMID = 24920890 }}</ref> | *[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428/figure/f1-copd-9-525/ SRIF (nih.gov)].<ref name=pmid24920890>{{Cite journal | last1 = Primiani | first1 = A. | last2 = Dias-Santagata | first2 = D. | last3 = Iafrate | first3 = AJ. | last4 = Kradin | first4 = RL. | title = Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. | journal = Int J Chron Obstruct Pulmon Dis | volume = 9 | issue = | pages = 525-31 | month = | year = 2014 | doi = 10.2147/COPD.S61932 | PMID = 24920890 }}</ref> | ||
*[http://www.nature.com/modpathol/journal/v25/n1s/fig_tab/modpathol2011154f4.html#figure-title SRIF (nature.com)].<ref name=pmid22214972>{{Cite journal | last1 = Katzenstein | first1 = AL. | title = Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP. | journal = Mod Pathol | volume = 25 Suppl 1 | issue = | pages = S68-78 | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.154 | PMID = 22214972 }}</ref> | |||
<!-- *[http://jcp.bmj.com/content/jclinpath/early/2013/04/26/jclinpath-2012-201338.full.pdf SRIF journal paper (bmj.com)]. --> | |||
==See also== | ==See also== | ||
*[[Smoking]]. | *[[Smoking]]. | ||
*[[Desquamative interstitial pneumonia]]. | |||
==References== | ==References== | ||