Difference between revisions of "Myoepithelioma"

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#redirect [[Salivary_glands#Myoepithelioma]]
'''Myoepithelioma''' is a tumour of the [[head and neck pathology|head and neck]].
 
==General==
*Usually benign.
**May be malignant; known as ''[[myoepithelial carcinoma]]'' and ''malignant myoepithelioma''.<ref name=pmid9762928>{{Cite journal  | last1 = Nagao | first1 = T. | last2 = Sugano | first2 = I. | last3 = Ishida | first3 = Y. | last4 = Tajima | first4 = Y. | last5 = Matsuzaki | first5 = O. | last6 = Konno | first6 = A. | last7 = Kondo | first7 = Y. | last8 = Nagao | first8 = K. | title = Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. | journal = Cancer | volume = 83 | issue = 7 | pages = 1292-9 | month = Oct | year = 1998 | doi =  | PMID = 9762928 }}</ref>
 
Location - head and neck:<ref name=pmid2982059>{{Cite journal  | last1 = Barnes | first1 = L. | last2 = Appel | first2 = BN. | last3 = Perez | first3 = H. | last4 = El-Attar | first4 = AM. | title = Myoepithelioma of the head and neck: case report and review. | journal = J Surg Oncol | volume = 28 | issue = 1 | pages = 21-8 | month = Jan | year = 1985 | doi =  | PMID = 2982059 }}</ref>
*Parotid gland ~50%.
*Palate ~25%
*Submandibular gland ~12%.
 
Notes:
*First described in 1972.<ref name=pmid5075358>{{Cite journal  | last1 = Saksela | first1 = E. | last2 = Tarkkanen | first2 = J. | last3 = Wartiovaara | first3 = J. | title = Parotid clear-cell adenoma of possible myoepithelial origin. | journal = Cancer | volume = 30 | issue = 3 | pages = 742-8 | month = Sep | year = 1972 | doi =  | PMID = 5075358 }}</ref>
*May be seen in the [[skin]].<ref name=pmid11224605>{{Cite journal  | last1 = Kutzner | first1 = H. | last2 = Mentzel | first2 = T. | last3 = Kaddu | first3 = S. | last4 = Soares | first4 = LM. | last5 = Sangueza | first5 = OP. | last6 = Requena | first6 = L. | title = Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 348-55 | month = Mar | year = 2001 | doi =  | PMID = 11224605 }}</ref>
 
==Microsopic==
Features:<ref name=Ref_DCHH130>{{Ref DCHH|130}}</ref>
*Myoepithelial cells - may be:
**Spindled.
**Plasmacytoid.
**Epithelioid.
**Clear (rare).
*Lack tubules, i.e. epithelial component.
**May be up to 10% (or 5%<ref>I. Weinreb. 24 October 2011.</ref>).
 
DDx:
*[[Pleomorphic adenoma]].
*[[Myoepithelial carcinoma]].
 
===Images===
<gallery>
Image: Myoepithelioma - low mag.jpg | Myoepithelioma - low mag. (WC/Nephron)
Image: Myoepithelioma_-_intermed_mag.jpg | Myoepithelioma - intermed. mag. (WC/Nephron)
Image: Myoepithelioma - high mag.jpg | Myoepithelioma - high mag. (WC/Nephron)
Image: Myoepithelioma_-_very_high_mag.jpg | Myoepithelioma - very high mag. (WC/Nephron)
</gallery>
 
==IHC==
Features:<ref name=Ref_DCHH130>{{Ref DCHH|130}}</ref>
*S100 +ve.
*GFAP +ve.
*CK14 +ve.
 
Others:<ref name=Ref_DCHH18>{{Ref DCHH|18}}</ref>
*SMA +ve.
*Calponin +ve.
 
==See also==
*[[Salivary gland]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]

Latest revision as of 01:49, 19 March 2019

Myoepithelioma is a tumour of the head and neck.

General

Location - head and neck:[2]

  • Parotid gland ~50%.
  • Palate ~25%
  • Submandibular gland ~12%.

Notes:

  • First described in 1972.[3]
  • May be seen in the skin.[4]

Microsopic

Features:[5]

  • Myoepithelial cells - may be:
    • Spindled.
    • Plasmacytoid.
    • Epithelioid.
    • Clear (rare).
  • Lack tubules, i.e. epithelial component.
    • May be up to 10% (or 5%[6]).

DDx:

Images

  • Myoepithelioma - low mag. (WC/Nephron)

  • Myoepithelioma - intermed. mag. (WC/Nephron)

  • Myoepithelioma - high mag. (WC/Nephron)

  • Myoepithelioma - very high mag. (WC/Nephron)

IHC

Features:[5]

  • S100 +ve.
  • GFAP +ve.
  • CK14 +ve.

Others:[7]

  • SMA +ve.
  • Calponin +ve.

See also

References

  1. ↑ Nagao, T.; Sugano, I.; Ishida, Y.; Tajima, Y.; Matsuzaki, O.; Konno, A.; Kondo, Y.; Nagao, K. (Oct 1998). "Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.". Cancer 83 (7): 1292-9. PMID 9762928.
  2. ↑ Barnes, L.; Appel, BN.; Perez, H.; El-Attar, AM. (Jan 1985). "Myoepithelioma of the head and neck: case report and review.". J Surg Oncol 28 (1): 21-8. PMID 2982059.
  3. ↑ Saksela, E.; Tarkkanen, J.; Wartiovaara, J. (Sep 1972). "Parotid clear-cell adenoma of possible myoepithelial origin.". Cancer 30 (3): 742-8. PMID 5075358.
  4. ↑ Kutzner, H.; Mentzel, T.; Kaddu, S.; Soares, LM.; Sangueza, OP.; Requena, L. (Mar 2001). "Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.". Am J Surg Pathol 25 (3): 348-55. PMID 11224605.
  5. ↑ 5.0 5.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 130. ISBN 978-0470519035.
  6. ↑ I. Weinreb. 24 October 2011.
  7. ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 18. ISBN 978-0470519035.
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