Difference between revisions of "Myoepithelioma"
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==General== | ==General== | ||
*Usually benign. | *Usually benign. | ||
**May be malignant.<ref name=pmid9762928>{{Cite journal | last1 = Nagao | first1 = T. | last2 = Sugano | first2 = I. | last3 = Ishida | first3 = Y. | last4 = Tajima | first4 = Y. | last5 = Matsuzaki | first5 = O. | last6 = Konno | first6 = A. | last7 = Kondo | first7 = Y. | last8 = Nagao | first8 = K. | title = Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. | journal = Cancer | volume = 83 | issue = 7 | pages = 1292-9 | month = Oct | year = 1998 | doi = | PMID = 9762928 }}</ref> | **May be malignant; known as ''[[myoepithelial carcinoma]]'' and ''malignant myoepithelioma''.<ref name=pmid9762928>{{Cite journal | last1 = Nagao | first1 = T. | last2 = Sugano | first2 = I. | last3 = Ishida | first3 = Y. | last4 = Tajima | first4 = Y. | last5 = Matsuzaki | first5 = O. | last6 = Konno | first6 = A. | last7 = Kondo | first7 = Y. | last8 = Nagao | first8 = K. | title = Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. | journal = Cancer | volume = 83 | issue = 7 | pages = 1292-9 | month = Oct | year = 1998 | doi = | PMID = 9762928 }}</ref> | ||
Location - head and neck:<ref name=pmid2982059>{{Cite journal | last1 = Barnes | first1 = L. | last2 = Appel | first2 = BN. | last3 = Perez | first3 = H. | last4 = El-Attar | first4 = AM. | title = Myoepithelioma of the head and neck: case report and review. | journal = J Surg Oncol | volume = 28 | issue = 1 | pages = 21-8 | month = Jan | year = 1985 | doi = | PMID = 2982059 }}</ref> | Location - head and neck:<ref name=pmid2982059>{{Cite journal | last1 = Barnes | first1 = L. | last2 = Appel | first2 = BN. | last3 = Perez | first3 = H. | last4 = El-Attar | first4 = AM. | title = Myoepithelioma of the head and neck: case report and review. | journal = J Surg Oncol | volume = 28 | issue = 1 | pages = 21-8 | month = Jan | year = 1985 | doi = | PMID = 2982059 }}</ref> | ||
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DDx: | DDx: | ||
*[[Pleomorphic adenoma]]. | *[[Pleomorphic adenoma]]. | ||
*[[ | *[[Myoepithelial carcinoma]]. | ||
===Images=== | ===Images=== | ||
Latest revision as of 01:49, 19 March 2019
Myoepithelioma is a tumour of the head and neck.
General
- Usually benign.
- May be malignant; known as myoepithelial carcinoma and malignant myoepithelioma.[1]
Location - head and neck:[2]
- Parotid gland ~50%.
- Palate ~25%
- Submandibular gland ~12%.
Notes:
Microsopic
Features:[5]
- Myoepithelial cells - may be:
- Spindled.
- Plasmacytoid.
- Epithelioid.
- Clear (rare).
- Lack tubules, i.e. epithelial component.
- May be up to 10% (or 5%[6]).
DDx:
Images
Myoepithelioma - low mag. (WC/Nephron)
Myoepithelioma - intermed. mag. (WC/Nephron)
Myoepithelioma - high mag. (WC/Nephron)
Myoepithelioma - very high mag. (WC/Nephron)
IHC
Features:[5]
- S100 +ve.
- GFAP +ve.
- CK14 +ve.
Others:[7]
- SMA +ve.
- Calponin +ve.
See also
References
- ↑ Nagao, T.; Sugano, I.; Ishida, Y.; Tajima, Y.; Matsuzaki, O.; Konno, A.; Kondo, Y.; Nagao, K. (Oct 1998). "Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.". Cancer 83 (7): 1292-9. PMID 9762928.
- ↑ Barnes, L.; Appel, BN.; Perez, H.; El-Attar, AM. (Jan 1985). "Myoepithelioma of the head and neck: case report and review.". J Surg Oncol 28 (1): 21-8. PMID 2982059.
- ↑ Saksela, E.; Tarkkanen, J.; Wartiovaara, J. (Sep 1972). "Parotid clear-cell adenoma of possible myoepithelial origin.". Cancer 30 (3): 742-8. PMID 5075358.
- ↑ Kutzner, H.; Mentzel, T.; Kaddu, S.; Soares, LM.; Sangueza, OP.; Requena, L. (Mar 2001). "Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.". Am J Surg Pathol 25 (3): 348-55. PMID 11224605.
- ↑ 5.0 5.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 130. ISBN 978-0470519035.
- ↑ I. Weinreb. 24 October 2011.
- ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 18. ISBN 978-0470519035.