Difference between revisions of "Myoepithelial carcinoma"
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'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]]. | '''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].<ref name=pmid9797738>{{Cite journal | last1 = McCluggage | first1 = WG. | last2 = Primrose | first2 = WJ. | last3 = Toner | first3 = PG. | title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. | journal = J Clin Pathol | volume = 51 | issue = 7 | pages = 552-6 | month = Jul | year = 1998 | doi = | PMID = 9797738 }}</ref> | ||
==General== | ==General== | ||
Revision as of 01:48, 19 March 2019
Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1] It is the malignant counterpart of myoepithelioma.[2]
General
- Rare.
- Often misdiagnosed as "benign".[3]
Microscopic
Features:[3]
- Myoepithelial cells - may be cytologically very bland.
- Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
- Pushing border ("expansile nodular lobulated pattern").
- No ductal structures.
Note:
- Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.
DDx:
IHC
- CAM5.2 +ve.
Molecular
See also
References
- ↑ Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
- ↑ McCluggage, WG.; Primrose, WJ.; Toner, PG. (Jul 1998). "Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma.". J Clin Pathol 51 (7): 552-6. PMID 9797738.
- ↑ 3.0 3.1 Xu, B.; Mneimneh, W.; Torrence, DE.; Higgins, K.; Klimstra, D.; Ghossein, R.; Katabi, N. (Feb 2019). "Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.". Am J Surg Pathol. doi:10.1097/PAS.0000000000001218. PMID 30789358.
- ↑ Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.
- ↑ Thway, K.; Bown, N.; Miah, A.; Turner, R.; Fisher, C. (Jun 2015). "Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors.". Head Neck Pathol 9 (2): 273-9. doi:10.1007/s12105-014-0556-2. PMID 24993038.