Difference between revisions of "Desmoplasia"

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'''Desmoplasia''', also '''desmoplastic response''' and '''desmoplastic stromal response''', is a stromal change associated with [[cancer]]. It is a finding that in the context of dysplasia supports a diagnosis of invasion.
'''Desmoplasia''' is the formation of fibrous connective tissue.<ref>URL: [http://www.merriam-webster.com/medical/desmoplasia http://www.merriam-webster.com/medical/desmoplasia]. Accessed on: 2 May 2013.</ref> It is also known as the '''desmoplastic response''', '''desmoplastic stroma''', '''desmoplastic stromal response''', and '''stromal response'''.
 
It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive [[carcinoma]].


==Microscopic==
==Microscopic==
Feature:<ref>{{Ref TPoSP|15}}</ref>
Features:
*Large (plump) spindle cells with relatively pale nuclei.
*Increased stromal cellularity - '''key feature'''.
*Increased cellular density.
**Large (plump) spindle cells (fibroblasts)‡ with (large) nuclei that are pale in relation to the tumour cells.
*Edema - pale spaces between the cells.
*Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref>
 
Note:
*‡ Large (plump) spindle cells: the nuclei have approximately the width of a resting lymphocyte.


DDx:
DDx:
*[[Sclerosing adenosis]].
*[[Sclerosing adenosis]].


Image:
===Images===
*[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCChp.JPG Desmoplasia in cervical SCC (ucsf.edu)].
<gallery>
Image:Cecal_adenocarcinoma.jpg | Desmoplasia in a cecal adenocarcinoma. (WC/Nephron)
Image:Colorectal adenocarcinoma - alt -- high mag.jpg | Desmoplasia in colorectal carcinoma. (WC/Nephron)
</gallery>
www:
*[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCChp.JPG Desmoplasia in cervical SCC (ucsf.edu)].<ref name=uscf>URL: [http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm]. Accessed on: 2 May 2013.</ref>


==See also==
==See also==
*[[Pseudoinvasion]].
*[[Pseudoinvasion]].
*[[Cancer]].
*[[Basics]].
*[[Nuclear atypia]].
*[[Nuclear pleomorphism]].


==References==
==References==

Latest revision as of 20:08, 6 December 2018

Desmoplasia is the formation of fibrous connective tissue.[1] It is also known as the desmoplastic response, desmoplastic stroma, desmoplastic stromal response, and stromal response.

It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive carcinoma.

Microscopic

Features:

  • Increased stromal cellularity - key feature.
    • Large (plump) spindle cells (fibroblasts)‡ with (large) nuclei that are pale in relation to the tumour cells.
  • Edema - pale spaces between the cells - may be apparent at low power.[2]

Note:

  • ‡ Large (plump) spindle cells: the nuclei have approximately the width of a resting lymphocyte.

DDx:

Images

  • Desmoplasia in a cecal adenocarcinoma. (WC/Nephron)

  • Desmoplasia in colorectal carcinoma. (WC/Nephron)

www:

See also

References

  1. ↑ URL: http://www.merriam-webster.com/medical/desmoplasia. Accessed on: 2 May 2013.
  2. ↑ Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 15. ISBN 978-0387744858.
  3. ↑ URL: http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm. Accessed on: 2 May 2013.
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