Keratins: Difference between revisions

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'''~~Keratins~~''' refers to a set of ~~immunostains~~ that mark filaments that are characteristic of epithelial cells and ~~cancer~~ derived from epithelial cells ([[carcinoma]]s).

In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s).

''Keratin'' when used in singular may refer to ''[[pankeratin]]''.

==Classification==

Divided by molecular weight:<ref>[http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]</ref>

*Low molecular weight keratins (LMWK): [[CK7|7]], 8/18, [[CK19|19]], [[CK20|20]].

*High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.

==Uses==

*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal |author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H |title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma |journal=Pathol. Res. Pract. |volume=189 |issue=8 |pages=888–93 |year=1993 |month=September |pmid=7508102 |doi= |url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes.

*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]].

==Sarcomas and keratins==

*Most sarcomas are cytokeratin negative.

Classic exceptions:

*[[Angiosarcoma]], epithelioid.

*[[Synovial sarcoma]].

*[[Chordoma]].

*[[Desmoplastic small round cell tumour]].

*[[Epithelioid sarcoma]].

Others:

*[[Leiomyosarcoma]].

==See also==

*[[Immunohistochemistry]].

*[[Pankeratin]].

==References==

[[Category:Immunohistochemistry]]

@@ Line 1: / Line 1: @@
-'''Keratins''' refers to a set of immunostains that mark filaments that are characteristic of epithelial cells and cancer derived from epithelial cells ([[carcinoma]]s).
+In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s).
 ''Keratin'' when used in singular may refer to ''[[pankeratin]]''.
+==Classification==
+Divided by molecular weight:<ref>[http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]</ref>
+*Low molecular weight keratins (LMWK): [[CK7|7]], 8/18, [[CK19|19]], [[CK20|20]].
+*High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.
+==Uses==
+*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal |author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H |title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma |journal=Pathol. Res. Pract. |volume=189 |issue=8 |pages=888–93 |year=1993 |month=September |pmid=7508102 |doi= |url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes.
+*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]].
+==Sarcomas and keratins==
+*Most sarcomas are cytokeratin negative.
+Classic exceptions:
+*[[Angiosarcoma]], epithelioid.
+*[[Synovial sarcoma]].
+*[[Chordoma]].
+*[[Desmoplastic small round cell tumour]].
+*[[Epithelioid sarcoma]].
+Others:
+*[[Leiomyosarcoma]].
 ==See also==
 *[[Immunohistochemistry]].
 *[[Pankeratin]].
+==References==
+{{Reflist|1}}
 [[Category:Immunohistochemistry]]

Keratins: Difference between revisions

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