Difference between revisions of "Neurocytoma"
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==Microscopic== | ==Microscopic== | ||
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm]. Accessed on: 12 October 2011.</ref> | Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm]. Accessed on: 12 October 2011.</ref> | ||
*[[Pineocytoma|Pineocytomatous]]/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | *[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
**Similar to Homer-Wright rosette. | **Similar to Homer-Wright rosette. | ||
*Monomorphic cells with round nuclei and speckled chromatin. | |||
*Perinuclear clearing. | *Perinuclear clearing. | ||
*Ganglion cell differentiation. | |||
*Well-defined cell borders. | *Well-defined cell borders. | ||
*Hyalinized vessels. | |||
*Necrosis absent. | |||
==IHC== | |||
*MIB-1: Usu. low. | |||
*Synapthophysin +ve. | |||
DDx: | DDx: | ||
| Line 15: | Line 24: | ||
*[[Ganglioglioma]]. | *[[Ganglioglioma]]. | ||
*[[Ependymoma]]. | *[[Ependymoma]]. | ||
*[[Pilocytic astrocytoma]] (with predominantly oligo-like cell component). | |||
* Diffuse leptomeningeal gliomeuronal tumour. | |||
===Images=== | |||
<gallery> | |||
File:Neurocytoma_Histopathology_HE.jpg | Neurocytoma (H&E: WC, Marvin101). | |||
File:Neurocytoma_NeuN.jpg | Nuclear NeuN immunoreactivity (WC, Marvin101): | |||
</gallery> | |||
www: | www: | ||
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm Neurocytoma (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm Neurocytoma (ouhsc.edu)]. | ||
*[http://path.upmc.edu/cases/case383.html Neurocytoma - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case383.html Neurocytoma - several images (upmc.edu)]. | ||
*[http://path.upmc.edu/cases/case561.html Neurocytoma - cerebellar - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case561.html Neurocytoma - cerebellar - several images (upmc.edu)]. | ||
==IHC== | ==IHC== | ||
*Synaptophysin +ve. | *Synaptophysin +ve. | ||
**Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref> | **Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref> | ||
==Molecular== | |||
*FGFR1-TACC1 fusions common.<ref>{{Cite journal | last1 = Sievers | first1 = P. | last2 = Stichel | first2 = D. | last3 = Schrimpf | first3 = D. | last4 = Sahm | first4 = F. | last5 = Koelsche | first5 = C. | last6 = Reuss | first6 = DE. | last7 = Wefers | first7 = AK. | last8 = Reinhardt | first8 = A. | last9 = Huang | first9 = K. | title = FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Jul | year = 2018 | doi = 10.1007/s00401-018-1882-3 | PMID = 29978331 }}</ref> | |||
==See also== | ==See also== | ||
Latest revision as of 12:07, 9 July 2018
Neurocytoma is a rare neuropathology tumour.
General
- Rare.
Microscopic
Features:[1]
- Pineocytomatous/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.[2]
- Similar to Homer-Wright rosette.
- Monomorphic cells with round nuclei and speckled chromatin.
- Perinuclear clearing.
- Ganglion cell differentiation.
- Well-defined cell borders.
- Hyalinized vessels.
- Necrosis absent.
IHC
- MIB-1: Usu. low.
- Synapthophysin +ve.
DDx:
- Oligodendroglioma - do not have the characteristic rosettes.
- Ganglioglioma.
- Ependymoma.
- Pilocytic astrocytoma (with predominantly oligo-like cell component).
- Diffuse leptomeningeal gliomeuronal tumour.
Images
Neurocytoma (H&E: WC, Marvin101).
Nuclear NeuN immunoreactivity (WC, Marvin101):
www:
- Neurocytoma (ouhsc.edu).
- Neurocytoma - several images (upmc.edu).
- Neurocytoma - cerebellar - several images (upmc.edu).
IHC
- Synaptophysin +ve.
- Most glial tumour -ve.[3]
Molecular
- FGFR1-TACC1 fusions common.[4]
See also
References
- ↑ URL: http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm. Accessed on: 12 October 2011.
- ↑ Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
- ↑ URL: http://path.upmc.edu/cases/case383/dx.html. Accessed on: 15 January 2012.
- ↑ Sievers, P.; Stichel, D.; Schrimpf, D.; Sahm, F.; Koelsche, C.; Reuss, DE.; Wefers, AK.; Reinhardt, A. et al. (Jul 2018). "FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.". Acta Neuropathol. doi:10.1007/s00401-018-1882-3. PMID 29978331.