Difference between revisions of "Small cell lymphomas"

Jump to navigation Jump to search

Small cell lymphomas (view source)

Revision as of 20:50, 16 June 2018

2,834 bytes added ,  20:50, 16 June 2018
hive off hairy cell leukemia to its own page
(create)
 
(hive off hairy cell leukemia to its own page)
 
(99 intermediate revisions by 2 users not shown)
Line 1: Line 1:
'''Small cell lymphomas''' are a collection of commonly seen lymphomas that have a near-identical histomorphologic appearance.
The '''small cell lymphomas''' are a collection of commonly seen [[lymphoma]]s that have a near-identical histomorphologic appearance.


The group includes:
The group includes:
#Small lymphocytic lymphoma/chronic lymphocytic leukemia.
#Small lymphocytic lymphoma/[[chronic lymphocytic leukemia]].
#Follicular lymphoma.
#[[Follicular lymphoma]].
#Mantle cell lymphoma.
#[[Mantle cell lymphoma]].
#Marginal zone lymphoma.
#[[Marginal zone lymphoma]] (includes ''[[MALT lymphoma]]'').
#Hairy cell leukemia.
#[[Hairy cell leukemia]].
#Immunoproliferative small intestinal disease (IPSID).<ref name=pmid15542584>{{cite journal |author=Al-Saleem T, Al-Mondhiry H |title=Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms |journal=Blood |volume=105 |issue=6 |pages=2274–80 |year=2005 |month=March |pmid=15542584 |doi=10.1182/blood-2004-07-2755 |url=http://bloodjournal.hematologylibrary.org/cgi/content/long/105/6/2274}}></ref>
#Immunoproliferative small intestinal disease (IPSID).<ref name=pmid15542584>{{cite journal |author=Al-Saleem T, Al-Mondhiry H |title=Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms |journal=Blood |volume=105 |issue=6 |pages=2274–80 |year=2005 |month=March |pmid=15542584 |doi=10.1182/blood-2004-07-2755 |url=http://bloodjournal.hematologylibrary.org/cgi/content/long/105/6/2274}}></ref>


Line 20: Line 20:
! Other
! Other
|-
|-
| Follicular lymphoma
| [[Follicular lymphoma]]
| Follicle
| Follicle
| Small, centrocytes, centroblasts
| Small, centrocytes, centroblasts
| CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD10+, BCL6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| t(14,18)
| t(14;18)(q32;q21) IGH/BCL2<ref name=pmid21192062>{{Cite journal  | last1 = Yanai | first1 = S. | last2 = Nakamura | first2 = S. | last3 = Takeshita | first3 = M. | last4 = Fujita | first4 = K. | last5 = Hirahashi | first5 = M. | last6 = Kawasaki | first6 = K. | last7 = Kurahara | first7 = K. | last8 = Sakai | first8 = Y. | last9 = Matsumoto | first9 = T. | title = Translocation t(14;18)/IGH-BCL2 in gastrointestinal follicular lymphoma: correlation with clinicopathologic features in 48 patients. | journal = Cancer | volume =  | issue =  | pages =  | month = Dec | year = 2010 | doi = 10.1002/cncr.25811 | PMID = 21192062 }}</ref>
| Clinical ?
| may transform into DLBCL
| Other ?
| very common
|-
|-
| Mantle cell lymphoma
| Mantle cell lymphoma
| Mantle zone
| mantle zone
| Small
| small
| CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD5+, [[CD23]]-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>
| t(11;14)(q13;q32) BCL1/IGH<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> (also IGH/BCL1<ref>URL: [http://www.wipo.int/patentscope/search/en/WO2010059499 http://www.wipo.int/patentscope/search/en/WO2010059499]. Accessed on: 26 May 2011.</ref>)
| Clinical ?
| aggressive, poor prognosis<ref name=pmid10583923>{{Cite journal  | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref>
| Other ?
| DDx: [[Castleman disease]]
|-
|-
| Marginal zone lymphoma (MALT)
| Marginal zone lymphoma (includes MALT)
| Marginal zone
| [[lymph node|marginal zone]], [[spleen]], GI tract
| Small
| small
| CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| Translocations
| t(11;18)(q21;q21) / API2‐MALT1, t(14;18)(q32;q21) / IGH‐MALT1, t(1;14)(p22;q32) / IGH‐BCL10<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref>
| Clinical
 
| Other
| classical GI lymphoma
| subtypes: extranodal marginal zone lymphoma ([[AKA]] MALT lymphoma), SMZL, nodal marginal zone lymphoma
|-
|-
| Precursor lymphoblastic lymphoma/leukemia
| Precursor B cell lymphoblastic lymphoma/leukemia
| Location ?
| location ?
| Small
| small
| CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| Translocations ?
| t(9;22), others
| Clinical ?
| good prognosis (?)
| Other ?
| other ?
|-
| B cell small lymphocytic lymphoma /<br>chronic lymphocytic leukemia
| location ?
| small
| CD5+, [[CD23]]+, CD43+, cyclin D1-
| trisomy 12; deletions of 11q, 13q, 17p<ref>{{Ref PCPBoD8|318}}</ref>
| good prognosis / indolent course
| other ?
|- <!--
| Name/entity ?
| location ?
| size of cells ?
| IHC ?
| translocations ?
| clinical ?
| other ? -->
|}
|}


Medium and large cell lymphomas:
Common medium and large cell lymphomas:
{| class="wikitable"
{| class="wikitable"
! Name
! Name
Line 60: Line 77:
! IHC
! IHC
! Translocations
! Translocations
! Clinical
! Clinical  
! Other
! Other
|-
|-
| Burkitt's lymphoma
| [[Burkitt's lymphoma]]
| Follicle
| follicle
| Large cells
| large cells
| CD10, bcl-6
| CD10, BCL6
| t(8;14) (q24;q32)  
| t(8;14) (q24;q32)  
| Rapid growth
| rapid growth
| "Starry sky"
| "starry sky"
|-
|-
| Diffuse large B cell lymphoma
| [[Diffuse large B cell lymphoma]]
| Follicle (?)
| follicle (?)
| Large 4-5X of lymphocyte
| large 4-5X of lymphocyte
| MIB-1 >40%
| MIB1 >40%
| none/like follicular l.
| none/like follicular l.
| Poor prognosis
| poor prognosis
| Common among lymphomas
| common among lymphomas
<!--
|-
|-
| Name
| Name
Line 85: Line 103:
| Translocations
| Translocations
| Clinical
| Clinical
| Other
| Other -->
|}
|}


==Follicular lymphoma==
==Follicular lymphoma==
*Abbreviated ''FL''.
{{Main|Follicular lymphoma}}
==Mantle cell lymphoma==
*Abbreviated ''MCL''.
{{Main|Mantle cell lymphoma}}
==Marginal zone lymphoma==
{{Main|Marginal zone lymphoma}}
Classification:
#Extranodal marginal zone lymphoma.
#*If in ''mucosa-associated lymphoid tissue'' known as a ''MALT lymphoma'', [[AKA]] ''MALToma''.
#Splenic marginal zone lymphoma (SMZL).
#Nodal marginal zone lymphoma (NMZL).
==Hairy cell leukemia==
See [[Hairy cell leukemia]]
==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==
{{Main|B cell small lymphocytic lymphoma/chronic lymphocytic leukemia}}
==Precursor B-cell lymphoblastic lymphoma/leukemia ==
===General===
===General===
*A very common type of lymphoma.
*Good prognosis.  
*Express Bcl-2.<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref>
*Paediatric - usu. <6 years old.


===Microscopic===
===Microscopic===
Features:
Features:<ref>DG. 17 August 2010.</ref>
*Abundant abnormal lymphoid follicles.
*High mitotic rate.
*"Starry sky" pattern.
*Small nucleoli.


===IHC===
===IHC===
Features:<ref name=pmid18359244/>
Features:<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
*CD10 +ve/-ve.
*CD10 +ve, TdT +ve, CD99 +ve.
*CD5 -ve.
*CD5 -ve.
**+ve in mantle cell lymphoma.
*CD23 -ve/+ve.
**+ve in CLL.
*CD43 -ve.
**+ve in mantle cell lymphoma, marginal zone lymphoma.
*CD11c -ve -- flow cytometry only.


===Molecular===
===Molecular===
*t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/>
Subclassification based on molecular abnormalities (translocations, rearrangements):<ref name=pmid15559730>{{cite journal |author=Randolph TR |title=Advances in acute lymphoblastic leukemia |journal=Clin Lab Sci |volume=17 |issue=4 |pages=235–45 |year=2004 |pmid=15559730 |url=http://findarticles.com/p/articles/mi_qa3890/is_200410/ai_n9429273/pg_2}}</ref>
**Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref>
* t(9;22) / BCR-ABL.
* t(1;19) / E2A-PBX1.
* t(12;21) / ETV-CBFalpha.
* MLL rearrangement.
 
==Precursor T-cell lymphoblastic lymphoma/leukemia ==
===General===
*Prognosis poor. (???)
 
===Microscopic===
Features:
*Small lymphoid cells. (???)
 
===IHC===
Features:<ref name=Ref_Lester97>{{Ref Lester|97}}</ref>
*TdT +ve, CD34 +ve, CD99 +ve, CD1a +ve/-ve.
*TIA1 -ve.


==See also==
==See also==
*[[Lymphoma]].
*[[Haematopathology]].
*[[Haematopathology]].
*[[Lymph node pathology]].
*[[Lymph node pathology]].
*[[Spleen]].


==References==
==References==
Line 120: Line 175:


[[Category:Haematopathology]]
[[Category:Haematopathology]]
[[Category:Small cell lymphomas]]
Mark
109

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/1390...49113"

Navigation menu