Difference between revisions of "Sclerosing mucoepidermoid carcinoma with eosinophilia"
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'''Sclerosing mucoepidermoid carcinoma with eosinophilia''' is an extremely rare tumour of the [[thyroid gland]]. | '''Sclerosing mucoepidermoid carcinoma with eosinophilia''' is an extremely rare tumour of the [[thyroid gland]]. | ||
==General== | ==General== | ||
* | Associated with: | ||
*Chronic thyroiditis, e.g. [[Hashimoto's thyroiditis]]. | |||
*Papillary thyroid carcinoma. | |||
==Microscopic== | ==Microscopic== | ||
| Line 20: | Line 13: | ||
DDx: | DDx: | ||
*[[Medullary thyroid carcinoma]]. | *[[Medullary thyroid carcinoma]]. | ||
*[[Mucoepidermoid carcinoma of the salivary gland]]. | *[[Mucoepidermoid carcinoma]] of the [[salivary gland]]. | ||
==Stains== | ==Stains== | ||
*Mucin stains +ve. | *Mucin stains +ve. | ||
==IHC== | |||
*TTF-1 +ve | |||
*Thyroglobulin -ve. | |||
*PAX8 +ve. | |||
*Calcitonin -ve. | |||
==Molecular== | ==Molecular== | ||
Latest revision as of 03:36, 20 March 2018
Sclerosing mucoepidermoid carcinoma with eosinophilia is an extremely rare tumour of the thyroid gland.
General
Associated with:
- Chronic thyroiditis, e.g. Hashimoto's thyroiditis.
- Papillary thyroid carcinoma.
Microscopic
Features:
- Mucous cells
- Squamoid differentiation.
DDx:
Stains
- Mucin stains +ve.
IHC
- TTF-1 +ve
- Thyroglobulin -ve.
- PAX8 +ve.
- Calcitonin -ve.
Molecular
- Negative for MAML2 rearrangements.[1]
See also
References
- ↑ Shah, AA.; La Fortune, K.; Miller, C.; Mills, SE.; Baloch, Z.; LiVolsi, V.; Dacic, S.; Mahaffey, AL. et al. (Mar 2017). "Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.". Mod Pathol 30 (3): 329-339. doi:10.1038/modpathol.2016.180. PMID 27910944.