Difference between revisions of "CNS cytopathology"

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==Things that don't smear well==
==Things that don't smear well==
Cohesive tumours:
Cohesive tumours:
*Meningioma.<ref name=pmid7962615>{{cite journal |author=Ironside JW |title=Update on central nervous system cytopathology. II. Brain smear technique |journal=J. Clin. Pathol. |volume=47 |issue=8 |pages=683–8 |year=1994 |month=August |pmid=7962615 |pmc=502135 |doi= |url=}}</ref><ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*[[Meningioma]].<ref name=pmid7962615>{{cite journal |author=Ironside JW |title=Update on central nervous system cytopathology. II. Brain smear technique |journal=J. Clin. Pathol. |volume=47 |issue=8 |pages=683–8 |year=1994 |month=August |pmid=7962615 |pmc=502135 |doi= |url=}}</ref><ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Neurofibroma.<ref name=pmid7962615/>
*[[Neurofibroma]].<ref name=pmid7962615/>
*[[Schwannoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*[[Schwannoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Metastasis.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Metastasis.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
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===Things that smear well===
===Things that smear well===
Dyscohesive tumours:
Dyscohesive tumours:
*Lymphoma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*[[Lymphoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Pituitary adenoma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*[[Pituitary adenoma]].<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Oligodendroglioma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*Oligodendroglioma.<ref name=Ref_TPoSP|252>{{Ref TPoSP|252}}</ref>
*[[Astrocytoma]].
*[[Astrocytoma]].

Revision as of 15:10, 11 April 2011

CNS cytopathology is a subset of neuropathology and cytopathology.

An introduction to cytopathology is in the cytopathology article. Cerebrospinal (CSF) specimens are dealt with in a separate article called CSF cytopathology.

Basic approach

 
 
 
 
 
 
 
 
CNS cytology
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Tumour
 
 
 
 
 
 
 
Non-tumour
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Glial
 
 
 
Non-glial
 
Infectious
 
 
 
Non-infectious
 
Glial Non-glial
Stranding
(cytoplasmic)
thin - cannot be seen at low
power (2.5x obj.), true cytoplasmic
processes
thick - can be seen at low
power (2.5x obj.), artifact of smearing
Edge of cluster smooth/non-distinct sharp

Glial vs non-glial:

Notes:

  • Crush artifact (in smear preparation) can mimic glial processes.
    • Crush artifact vs. real glial processes:
      • No glial processes run perpendicular to the direction of smear.
      • Glial processes may branch.
      • Crushed/elongated nuclei are present in artifactual processes.

Metastatic carcinoma

Things that don't smear well

Cohesive tumours:

Things that smear well

Dyscohesive tumours:

See also

References

  1. 1.0 1.1 URL: http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html. Accessed on: 2 November 2010.
  2. URL: http://moon.ouhsc.edu/kfung/JTY1/NeuroTest/Q92-Ans.htm. Accessed on: 3 November 2010.
  3. 3.0 3.1 Ironside JW (August 1994). "Update on central nervous system cytopathology. II. Brain smear technique". J. Clin. Pathol. 47 (8): 683–8. PMC 502135. PMID 7962615. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC502135/.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 252. ISBN 978-0387744858.

External links