Difference between revisions of "Giant cell tumour of tendon sheath"

From Libre Pathology
Jump to navigation Jump to search
(redirect)
 
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
#redirect [[Chondro-osseous_tumours#Giant_cell_tumour_of_tendon_sheath]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Giant cell tumour of the tendon sheath -- very high mag.jpg
| Width      =
| Caption    = GCT of tendon sheath. [[H&E stain]].
| Micro      = foam cells, multinucleated giant cells (may be scarce), +/-tendon, +/-hemosiderin-laden macrophages
| Subtypes  =
| LMDDx      = [[giant cell lesions]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = circumscribed mass - yellow-brown to tan
| Grossing  =
| Site      = hand - classic site
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good (benign), can be malignant (rare)
| Other      =
| ClinDDx    =
}}
'''Giant cell tumour of tendon sheath''' is a relatively common tumour of small [[joints]]. It is grouped with the [[chondro-osseous tumours]].  It is abbreviated '''GCT of tendon sheath'''.
 
''Fibroma of tendon sheath'' (abbreviated ''FTS'') redirect to this article.
 
==General==
*Can be thought of as the small joint version of [[diffuse tenosynovial giant-cell tumour]] ([[AKA]] ''PVNS'').<ref name=Ref_DCHH341>{{Ref DCHH|341-2}}</ref>
*Rarely recur.
*Classically afflicts the hand.<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
*Rarely malignant.<ref name=pmid19094761>{{Cite journal  | last1 = Pan | first1 = YW. | last2 = Huang | first2 = XY. | last3 = You | first3 = JF. | last4 = Tian | first4 = GL. | last5 = Li | first5 = C. | title = [Malignant giant cell tumor of the tendon sheaths in the hand]. | journal = Zhonghua Wai Ke Za Zhi | volume = 46 | issue = 21 | pages = 1645-8 | month = Nov | year = 2008 | doi =  | PMID = 19094761 }}</ref><ref name=pmid8230758>{{Cite journal  | last1 = Shinjo | first1 = K. | last2 = Miyake | first2 = N. | last3 = Takahashi | first3 = Y. | title = Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. | journal = Jpn J Clin Oncol | volume = 23 | issue = 5 | pages = 317-24 | month = Oct | year = 1993 | doi =  | PMID = 8230758 }}</ref>
 
==Gross==
Features:<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
*Circumscribed mass - yellow-brown to tan.
 
Note:
*May be associated with bony erosions in larger lesions.<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
 
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122708/figure/Fig2/ GCT of tendon sheath (nih.gov)].<ref name=pmid22282671>{{Cite journal  | last1 = Suresh | first1 = SS. | last2 = Zaki | first2 = H. | title = Giant cell tumor of tendon sheath: case series and review of literature. | journal = J Hand Microsurg | volume = 2 | issue = 2 | pages = 67-71 | month = Dec | year = 2010 | doi = 10.1007/s12593-010-0020-9 | PMID = 22282671 }}</ref>
 
==Microscopic==
Features:<ref name=Ref_DCHH341>{{Ref DCHH|341-2}}</ref>
*Foam cells.
**Cells with moderate to abundant foamy-appearing cytoplasm.
*Multinucleated giant cells - may be scarce.
*+/-Tendon.
**Dense connective tissue.
*+/-Hemosiderin-laden macrophages.
 
Note:
*Features of malignancy: nuclear pleomorphism,<ref name=pmid8230758>{{Cite journal  | last1 = Shinjo | first1 = K. | last2 = Miyake | first2 = N. | last3 = Takahashi | first3 = Y. | title = Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. | journal = Jpn J Clin Oncol | volume = 23 | issue = 5 | pages = 317-24 | month = Oct | year = 1993 | doi =  | PMID = 8230758 }}</ref> abnormal mitoses, >10 mitoses/[[HPF]], tumour necrosis lack of maturation to superficial part (nuclei shrink, cytoplasm lipid-ified).<ref name=Ref_DCHH341>{{Ref DCHH|341-2}}</ref>
 
DDx:
*[[Giant cell lesions]].
*Plexiform fibrohistiocytoma.{{fact}}
*Fibroma of tendon sheath (FTS) - if one believes it is a separate entity.<ref>{{Cite journal  | last1 = Heckert | first1 = R. | last2 = Bear | first2 = J. | last3 = Summers | first3 = T. | last4 = Frew | first4 = M. | last5 = Gwinn | first5 = D. | last6 = McKay | first6 = P. | title = Fibroma of the tendon sheath - a rare hand tumor. | journal = Pol Przegl Chir | volume = 84 | issue = 12 | pages = 651-6 | month = Dec | year = 2012 | doi = 10.2478/v10035-012-0107-z | PMID = 23399633 }}</ref>
**IHC suggests ''FTS'' and ''GCT of tendon sheath'' are one entity.<Ref name=pmid7777476>{{Cite journal  | last1 = Maluf | first1 = HM. | last2 = DeYoung | first2 = BR. | last3 = Swanson | first3 = PE. | last4 = Wick | first4 = MR. | title = Fibroma and giant cell tumor of tendon sheath: a comparative histological and immunohistological study. | journal = Mod Pathol | volume = 8 | issue = 2 | pages = 155-9 | month = Feb | year = 1995 | doi =  | PMID = 7777476 }}</ref>
 
===Images===
<gallery>
Image: Giant cell tumour of the tendon sheath -- intermed mag.jpg | GCT of tendon sheath - intermed. mag. (WC)
Image: Giant cell tumour of the tendon sheath -- high mag.jpg | GCT of tendon sheath - high mag. (WC)
Image: Giant cell tumour of the tendon sheath -- very high mag.jpg | GCT of tendon sheath - very high mag. (WC)
</gallery>
<gallery>
Image:Giant_cell_tumor_of_tendon_sheath_histopathology%281%29.jpg | GCT of tendon sheath. (WC/KGH)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=1&Case=484 GCT of tendon sheath - very low mag. (webpathology.com)]
*[http://www.webpathology.com/image.asp?case=484&n=5 GCT of tendon sheath - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=4&Case=484 GCT of tendon sheath - high mag. (webpathology.com)].
 
==Sign out==
<pre>
Submitted as "Giant Cell Tumour Right Long Finger", Excision:
- Giant cell tumour of tendon sheath.
</pre>
 
===Block letters===
<pre>
LESION, RIGHT INDEX FINGER, EXCISION:
- GIANT CELL TUMOUR OF THE TENDON SHEATH.
</pre>
 
===Micro===
The sections show histiocytes and rare multinucleated giant cells on a background of dense connective tissue compatible with tendon.  No nuclear atypia is apparent.  Rare mitotic activity is identified.  No atypical mitoses are apparent.
 
====Alternate====
The sections show histiocyte-like cells and rare multinucleated giant cells on a background of dense
connective tissue compatible with tendon. Hemosiderin-laden macrophages are present. No
nuclear atypia is apparent. No mitotic activity is apparent.
 
==See also==
*[[Chondro-osseous tumours]].
*[[Diffuse tenosynovial giant-cell tumour]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Chondro-osseous tumours]]

Latest revision as of 21:46, 11 October 2017

Giant cell tumour of tendon sheath
Diagnosis in short

GCT of tendon sheath. H&E stain.
LM foam cells, multinucleated giant cells (may be scarce), +/-tendon, +/-hemosiderin-laden macrophages
LM DDx giant cell lesions
Gross circumscribed mass - yellow-brown to tan
Site hand - classic site
Prognosis good (benign), can be malignant (rare)

Giant cell tumour of tendon sheath is a relatively common tumour of small joints. It is grouped with the chondro-osseous tumours. It is abbreviated GCT of tendon sheath.

Fibroma of tendon sheath (abbreviated FTS) redirect to this article.

General

Gross

Features:[2]

  • Circumscribed mass - yellow-brown to tan.

Note:

  • May be associated with bony erosions in larger lesions.[2]

Image:

Microscopic

Features:[1]

  • Foam cells.
    • Cells with moderate to abundant foamy-appearing cytoplasm.
  • Multinucleated giant cells - may be scarce.
  • +/-Tendon.
    • Dense connective tissue.
  • +/-Hemosiderin-laden macrophages.

Note:

  • Features of malignancy: nuclear pleomorphism,[4] abnormal mitoses, >10 mitoses/HPF, tumour necrosis lack of maturation to superficial part (nuclei shrink, cytoplasm lipid-ified).[1]

DDx:

  • Giant cell lesions.
  • Plexiform fibrohistiocytoma.[citation needed]
  • Fibroma of tendon sheath (FTS) - if one believes it is a separate entity.[6]
    • IHC suggests FTS and GCT of tendon sheath are one entity.[7]

Images

  • GCT of tendon sheath - intermed. mag. (WC)

  • GCT of tendon sheath - high mag. (WC)

  • GCT of tendon sheath - very high mag. (WC)

  • GCT of tendon sheath. (WC/KGH)

www:

Sign out

Submitted as "Giant Cell Tumour Right Long Finger", Excision:
- Giant cell tumour of tendon sheath.

Block letters

LESION, RIGHT INDEX FINGER, EXCISION:
- GIANT CELL TUMOUR OF THE TENDON SHEATH.

Micro

The sections show histiocytes and rare multinucleated giant cells on a background of dense connective tissue compatible with tendon. No nuclear atypia is apparent. Rare mitotic activity is identified. No atypical mitoses are apparent.

Alternate

The sections show histiocyte-like cells and rare multinucleated giant cells on a background of dense connective tissue compatible with tendon. Hemosiderin-laden macrophages are present. No nuclear atypia is apparent. No mitotic activity is apparent.

See also

References

  1. ↑ 1.0 1.1 1.2 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 341-2. ISBN 978-0470519035.
  2. ↑ 2.0 2.1 2.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 612. ISBN 978-0781765275.
  3. ↑ Pan, YW.; Huang, XY.; You, JF.; Tian, GL.; Li, C. (Nov 2008). "[Malignant giant cell tumor of the tendon sheaths in the hand].". Zhonghua Wai Ke Za Zhi 46 (21): 1645-8. PMID 19094761.
  4. ↑ 4.0 4.1 Shinjo, K.; Miyake, N.; Takahashi, Y. (Oct 1993). "Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature.". Jpn J Clin Oncol 23 (5): 317-24. PMID 8230758.
  5. ↑ Suresh, SS.; Zaki, H. (Dec 2010). "Giant cell tumor of tendon sheath: case series and review of literature.". J Hand Microsurg 2 (2): 67-71. doi:10.1007/s12593-010-0020-9. PMID 22282671.
  6. ↑ Heckert, R.; Bear, J.; Summers, T.; Frew, M.; Gwinn, D.; McKay, P. (Dec 2012). "Fibroma of the tendon sheath - a rare hand tumor.". Pol Przegl Chir 84 (12): 651-6. doi:10.2478/v10035-012-0107-z. PMID 23399633.
  7. ↑ Maluf, HM.; DeYoung, BR.; Swanson, PE.; Wick, MR. (Feb 1995). "Fibroma and giant cell tumor of tendon sheath: a comparative histological and immunohistological study.". Mod Pathol 8 (2): 155-9. PMID 7777476.
Retrieved from "https://librepathology.org/w/index.php?title=Giant_cell_tumour_of_tendon_sheath&oldid=48017"