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Difference between revisions of "Bullous diseases"
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→Pemphigoid gestationis: added a case
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An introduction to skin pathology is in the ''[[dermatopathology]]'' article. An introduction to inflammatory skin lesions in the ''[[non-malignant skin disease]]'' article. | An introduction to skin pathology is in the ''[[dermatopathology]]'' article. An introduction to inflammatory skin lesions in the ''[[non-malignant skin disease]]'' article. | ||
Bullous disease of the [[lung]] is dealt with in ''[[lung bullae]]''. | |||
=Overview= | =Overview= | ||
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*[[Staphylococcal scalded skin syndrome]]. | *[[Staphylococcal scalded skin syndrome]]. | ||
*[[Bullous impetigo]]. | *[[Bullous impetigo]]. | ||
===IF=== | |||
*Desmoglein 1 - abnormal. | |||
==Bullous pemphigoid== | ==Bullous pemphigoid== | ||
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*[[AKA]] ''pemphigus''. | *[[AKA]] ''pemphigus''. | ||
===General=== | ===General=== | ||
*May lead to blindness. | |||
*Oral lesion is classically: ''first to show & last to go''. | |||
**Oral lesions usually precede the skin lesions. | |||
Classic presentation: | Classic presentation: | ||
*Mouth lesions. | *Mouth lesions. | ||
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Features: | Features: | ||
*Suprabasilar blistering. | *Suprabasilar blistering. | ||
*Acanthosis (thick epidermis). | *[[Acanthosis]] (thick epidermis). | ||
Notes: | Notes: | ||
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#[[Darier disease]]. | #[[Darier disease]]. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Transient acantholytic dermatosis - intermed mag.jpg | Grover disease - intermed. mag. (WC) | |||
Image:Transient_acantholytic_dermatosis_-_high_mag.jpg | Grover disease - high mag. (WC) | |||
Image:Transient_acantholytic_dermatosis_-_very_high_mag.jpg | Grover disease - very high mag. (WC) | |||
</gallery> | |||
==Acute generalized exanthematous pustulosis== | ==Acute generalized exanthematous pustulosis== | ||
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*Eosinophils - abundant. | *Eosinophils - abundant. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Pemphigoid_gestationis_-_low_mag.jpg | PG - low mag. (WC) | |||
Image:Pemphigoid_gestationis_-_high_mag.jpg | PG - high mag. (WC) | |||
Image:Pemphigoid_gestationis_-_very_high_mag.jpg | PG - very high mag. (WC) | |||
</gallery> | |||
===IF=== | ===IF=== | ||
*C3 linear pattern at DE junction - diagnostic.<ref name=pmid21877502>{{Cite journal | last1 = Campbell | first1 = SM. | last2 = Balazs | first2 = K. | last3 = Conroy | first3 = M. | title = Pemphigoid gestationis: a case report and review of the literature. | journal = Cutis | volume = 88 | issue = 1 | pages = 21-6 | month = Jul | year = 2011 | doi = | PMID = 21877502 }}</ref> | *C3 linear pattern at DE junction - diagnostic.<ref name=pmid21877502>{{Cite journal | last1 = Campbell | first1 = SM. | last2 = Balazs | first2 = K. | last3 = Conroy | first3 = M. | title = Pemphigoid gestationis: a case report and review of the literature. | journal = Cutis | volume = 88 | issue = 1 | pages = 21-6 | month = Jul | year = 2011 | doi = | PMID = 21877502 }}</ref> | ||
==Bullous Arthropod Assault== | |||
[[File:30MR17 dp sl 1.png|Bullous arthropod assault]] | |||
[[File:30MR17 dp sl 2.png|Bullous arthropod assault]] | |||
[[File:30MR17 dp sl 3.png|Bullous arthropod assault]]<br> | |||
Bullous arthropod assault. A. Beneath intraepidermal blistering lies superficial and deep inflammation with extension into fat. B. The vesicle shows spongiotic epidermis at base and multiple eosinophils. C. Eosinophils are prominent in dermal and adipose tissue inflammation. | |||
=See also= | =See also= | ||