Difference between revisions of "Tubulocystic carcinoma of the kidney"

Jump to navigation Jump to search

Tubulocystic carcinoma of the kidney (view source)

Revision as of 18:14, 28 February 2017

1,532 bytes added ,  18:14, 28 February 2017
→‎Microscopic
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Tubulocystic renal cell carcinoma -- low mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Tubulocystic renal cell carcinoma. [[H&E stain]].
| Synonyms  = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
| Synonyms  = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
| Micro      = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
| Micro      = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or [[hobnail morphology]], eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
| Subtypes  =
| Subtypes  =
| LMDDx      = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]
| LMDDx      = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]
Line 14: Line 14:
| IF        =
| IF        =
| Gross      = multicystic lesion (bubble wrap-like appearance)
| Gross      = multicystic lesion (bubble wrap-like appearance)
| Grossing  =
| Grossing  = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]
| Staging    = [[kidney cancer staging]]
| Site      = [[kidney]]
| Site      = [[kidney]]
| Assdx      =
| Assdx      =
Line 31: Line 32:
}}
}}
'''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]].
'''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]].
In the [[Vancouver classification|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>


It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>
It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>
In the [[Vancouver classification|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>


It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]].
It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]].
Line 51: Line 52:
Features:.<ref name=pmid19011562/>
Features:.<ref name=pmid19011562/>
*Cysts of variable size lined by a single layer of epithelium that has a:
*Cysts of variable size lined by a single layer of epithelium that has a:
**Cuboidal, flat, or hobnail morphology.
**Cuboidal, flat, or [[hobnail morphology]].
**Eosinophilic cytoplasm.
**Eosinophilic cytoplasm.
**Large nuclei with prominent nucleoli.  
**Large nuclei with prominent nucleoli.  
Line 58: Line 59:
DDx:
DDx:
*[[Papillary renal cell carcinoma]] (oncocytic variant).
*[[Papillary renal cell carcinoma]] (oncocytic variant).
*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].
*[[Renal oncocytoma]].  
*[[Renal oncocytoma]].  
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
*[[Multilocular cystic renal cell carcinoma]].
*[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma).
*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].


===Images===
===Images===
====Case 1====
<gallery>
Image: Tubulocystic renal cell carcinoma -- very low mag.jpg | TC-RCC - very low mag.
Image: Tubulocystic renal cell carcinoma -- low mag.jpg | TC-RCC - low mag.
Image: Tubulocystic renal cell carcinoma -- intermed mag.jpg | TC-RCC - intermed. mag.
Image: Tubulocystic renal cell carcinoma -- high mag.jpg | TC-RCC - high mag.
Image: Tubulocystic renal cell carcinoma -- very high mag.jpg | TC-RCC - very high mag.
Image: Tubulocystic renal cell carcinoma - alt -- low mag.jpg | TC-RCC - low mag.
Image: Tubulocystic renal cell carcinoma - alt -- intermed mag.jpg | TC-RCC - intermed. mag.
Image: Tubulocystic renal cell carcinoma - alt -- high mag.jpg | TC-RCC - high mag.
Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg | TC-RCC - very high mag.
</gallery>
====Case 2====
<gallery>
Image: Tubulocystic carcinoma of the kidney -- low mag.jpg | TC - low mag.
Image: Tubulocystic carcinoma of the kidney -- intermed mag.jpg | TC - intermed. mag.
Image: Tubulocystic carcinoma of the kidney -- high mag.jpg | TC - high mag.
Image: Tubulocystic carcinoma of the kidney -- very high mag.jpg | TC - very high mag.
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref>
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref>
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].
Line 73: Line 95:
*RCC +ve.
*RCC +ve.
*Vimentin +ve.
*Vimentin +ve.
*AMACR +ve.
*[[AMACR]] +ve.
*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal  | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi =  | PMID = 23157747 }}</ref>).
*[[CK7]] -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal  | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi =  | PMID = 23157747 }}</ref>).
 
Notes:
*IHC profile essentially that of [[PaRCC]].{{fact}}


==See also==
==See also==
Michael
49,006

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/36224...47023"

Navigation menu