Solitary fibrous tumour: Difference between revisions
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Jensflorian (talk | contribs) Update NAB2-STAT6 fusions as specific marker for SFT/hemangiopericytoma |
Jensflorian (talk | contribs) →Images: STAT6 added. |
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*May be associated with hypoglycemia. | *May be associated with hypoglycemia. | ||
**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | volume = 90 | issue = 11 | pages = 557-60 | month = Nov | year = 1992 | doi = | PMID = 1474302 }}</ref> | **Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | volume = 90 | issue = 11 | pages = 557-60 | month = Nov | year = 1992 | doi = | PMID = 1474302 }}</ref> | ||
*Leptomeningeal SFTs/hemangiopericytomas are classified as WHO grade II | *Leptomeningeal SFTs/hemangiopericytomas are classified as follows: | ||
** WHO grade I: classical SFT | |||
** WHO grade II: classical [[hemangiopericytoma]] | |||
** WHO grade III: anaplastic hemangiopericytoma / malignant SFT | |||
==Gross== | ==Gross== | ||
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Image:Solitary_fibrous_tumour_intermed_mag.jpg | Benign SFT - intermed. mag. (WC) | Image:Solitary_fibrous_tumour_intermed_mag.jpg | Benign SFT - intermed. mag. (WC) | ||
Image:Solitary_fibrous_tumour_high_mag.jpg | Benign SFT - high mag. (WC) | Image:Solitary_fibrous_tumour_high_mag.jpg | Benign SFT - high mag. (WC) | ||
File:Neuropathology_case_VI_01.jpg | Nuclear STAT6 immunoreactivity in malignant SFT (WC/jensflorian) | |||
</gallery> | </gallery> | ||
www: | www: | ||
*[http://path.upmc.edu/cases/case272.html SFT of the brain - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case272.html SFT of the brain - several images (upmc.edu)]. | ||
Malignant solitary fibrous tumor (low to intermediate grade tumor). 15 cm mass in upper arm of 50 year old man.<ref>Am J Surg Pathol 2014;38:552-559</ref> | |||
<gallery> | |||
File:3 18039322534203 sl 1.png|malignant solitary fibrous tumor | Hypocellular (green arrow) and hypercellular (cyan arrow) areas alternate. | |||
File:3 18039322534203 sl 2.png|malignant solitary fibrous tumor | Vascular spaces suggest antlers (staghorn). Note subcapsular hemorrhage. | |||
File:3 18039322534203 sl 3.png|malignant solitary fibrous tumor | Stromal hyalinization | |||
File:3 18039322534203 sl 4.png|malignant solitary fibrous tumor | Nuclei, lacking organization, show varied size and shape, with some cells being round to ovoid. The arrow points to myxoid focus in stroma. When a majority of the following are present, a low to intermediate grade malignant solitary fibrous tumor is present: 1) size > 5 cm (this case), 2) pleomorphism with round cells/epithelioid cells (this case), 3) subcapsular hemorrhage (this case), 4) ≥4 mitoses per 10 high power fields, 5) necrosis with perivascular tumor sparing. STAT 6 positivity is very helpful in separating this tumor from its mimics | |||
</gallery> | |||
==IHC== | ==IHC== | ||