Eosinophilic granulomatosis with polyangiitis: Difference between revisions

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split out
 
Michael (talk | contribs)
49,300 edits
similar name to what was prev Wegener's
 
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'''Eosinophilic granulomatosis with polyangiitis''', previously known as '''Churg-Strauss syndrome''',<ref name=pmid26051917>{{Cite journal  | last1 = Stone | first1 = JR. | last2 = Bruneval | first2 = P. | last3 = Angelini | first3 = A. | last4 = Bartoloni | first4 = G. | last5 = Basso | first5 = C. | last6 = Batoroeva | first6 = L. | last7 = Buja | first7 = LM. | last8 = Butany | first8 = J. | last9 = d'Amati | first9 = G. | title = Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. | journal = Cardiovasc Pathol | volume = 24 | issue = 5 | pages = 267-78 | month = | year = | doi = 10.1016/j.carpath.2015.05.001 | PMID = 26051917 }}</ref> is a type of [[vasculitis]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Churg-Strauss_syndrome_-_high_mag.jpg
| Width      =
| Caption    = Eosinophilic granulomatosis with polyangiitis. [[H&E stain]].
| Synonyms  = Churg-Strauss syndrome, Churg-Strauss disease
| Micro      = small vessel [[vasculitis]] with abundant eosinophils and [[granuloma]]s
| Subtypes  =
| LMDDx      = eosinophilic vasculitis associated with a [[connective tissue disease]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[blood vessels]]
| Assdx      = [[asthma]]
| Syndromes  =
| Clinicalhx =
| Signs      = fever
| Symptoms  =
| Prevalence = rare
| Bloodwork  = ANCA +ve/-ve
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Eosinophilic granulomatosis with polyangiitis''', abbreviated '''EGPA''',<ref>{{Cite journal  | last1 = Xu | first1 = XL. | last2 = Song | first2 = W. | last3 = Sui | first3 = X. | last4 = Song | first4 = L. | last5 = DU | first5 = QN. | last6 = Wang | first6 = X. | title = Radiological and Clinical Features of Eosinophilic Granulomatosis with Polyangiitis. | journal = Zhongguo Yi Xue Ke Xue Yuan Xue Bao | volume = 38 | issue = 5 | pages = 617-620 | month = Oct | year = 2016 | doi = 10.3881/j.issn.1000-503X.2016.05.023 | PMID = 27825424 }}</ref> is a type of [[vasculitis]].


It is also known as ''allergic granulomatous angiitis''.<ref name=emedicine333492>[http://emedicine.medscape.com/article/333492-overview http://emedicine.medscape.com/article/333492-overview]</ref>
It was previously known as '''Churg-Strauss syndrome'''.<ref name=pmid26051917>{{Cite journal  | last1 = Stone | first1 = JR. | last2 = Bruneval | first2 = P. | last3 = Angelini | first3 = A. | last4 = Bartoloni | first4 = G. | last5 = Basso | first5 = C. | last6 = Batoroeva | first6 = L. | last7 = Buja | first7 = LM. | last8 = Butany | first8 = J. | last9 = d'Amati | first9 = G. | title = Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. | journal = Cardiovasc Pathol | volume = 24 | issue = 5 | pages = 267-78 | month =  | year =  | doi = 10.1016/j.carpath.2015.05.001 | PMID = 26051917 }}</ref>
It should '''''not''''' be confused with ''[[granulomatosis with polyangiitis]]'', previously known as ''Wegener's granulomatosis''.


==General==
==General==
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*'''F'''ever.
*'''F'''ever.
*'''E'''osinophilia.
*'''E'''osinophilia.
Other clinical features - may be present:<ref name=pmid27671089 >{{Cite journal  | last1 = Cottin | first1 = V. | last2 = Bel | first2 = E. | last3 = Bottero | first3 = P. | last4 = Dalhoff | first4 = K. | last5 = Humbert | first5 = M. | last6 = Lazor | first6 = R. | last7 = Sinico | first7 = RA. | last8 = Sivasothy | first8 = P. | last9 = Wechsler | first9 = ME. | title = Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss). | journal = Autoimmun Rev | volume =  | issue =  | pages =  | month = Sep | year = 2016 | doi = 10.1016/j.autrev.2016.09.018 | PMID = 27671089 }}</ref>
*ANCA.
*Weight loss.
*Myalgias.
*Arthralgias
*Glomerulonephritis.
*Hematuria.


Notes:
Notes:
*Similar to ''[[Wegener's granulomatosis]]'' (classically c-ANCA +ve) and ''microscopic polyangiitis''.<ref>URL: [http://emedicine.medscape.com/article/334024-overview http://emedicine.medscape.com/article/334024-overview]. Accessed on: 22 January 2011.</ref>
*Similar to [[Granulomatosis with polyangiitis]] (Wegener's granulomatosis) - classically c-ANCA +ve, and ''microscopic polyangiitis''.<ref>URL: [http://emedicine.medscape.com/article/334024-overview http://emedicine.medscape.com/article/334024-overview]. Accessed on: 22 January 2011.</ref>
*T<sub>H</sub>2 disease - like [[asthma]].<ref name=pmid25500434>{{Cite journal  | last1 = Greco | first1 = A. | last2 = Rizzo | first2 = MI. | last3 = De Virgilio | first3 = A. | last4 = Gallo | first4 = A. | last5 = Fusconi | first5 = M. | last6 = Ruoppolo | first6 = G. | last7 = Altissimi | first7 = G. | last8 = De Vincentiis | first8 = M. | title = Churg-Strauss syndrome. | journal = Autoimmun Rev | volume = 14 | issue = 4 | pages = 341-8 | month = Apr | year = 2015 | doi = 10.1016/j.autrev.2014.12.004 | PMID = 25500434 }}</ref>


==Microscopic==
==Microscopic==
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