Difference between revisions of "NSAID enteropathy"
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'''NSAID enteropathy''' is inflammation of the [[small intestine]] due to a [[Non-steroidal anti-inflammatory drug (NSAID)]]. | '''NSAID enteropathy''' is inflammation of the [[small intestine]] due to a [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory drug (NSAID)]]. | ||
==General== | ==General== | ||
*[[Clinical diagnosis]]. | *[[Clinical diagnosis]]. | ||
*NSAID use - such as in [[rheumatoid arthritis]] or [[osteoarthritis]].<ref>{{Cite journal | last1 = Tachecí | first1 = I. | last2 = Bradna | first2 = P. | last3 = Douda | first3 = T. | last4 = Baštecká | first4 = D. | last5 = Kopáčová | first5 = M. | last6 = Rejchrt | first6 = S. | last7 = Lutonský | first7 = M. | last8 = Soukup | first8 = T. | last9 = Bureš | first9 = J. | title = Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis. | journal = Rheumatol Int | volume = 36 | issue = 11 | pages = 1557-1561 | month = Nov | year = 2016 | doi = 10.1007/s00296-016-3552-x | PMID = 27549792 }}</ref> | *NSAID use - such as in [[rheumatoid arthritis]] or [[osteoarthritis]].<ref>{{Cite journal | last1 = Tachecí | first1 = I. | last2 = Bradna | first2 = P. | last3 = Douda | first3 = T. | last4 = Baštecká | first4 = D. | last5 = Kopáčová | first5 = M. | last6 = Rejchrt | first6 = S. | last7 = Lutonský | first7 = M. | last8 = Soukup | first8 = T. | last9 = Bureš | first9 = J. | title = Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis. | journal = Rheumatol Int | volume = 36 | issue = 11 | pages = 1557-1561 | month = Nov | year = 2016 | doi = 10.1007/s00296-016-3552-x | PMID = 27549792 }}</ref> | ||
*The pathobiology of NSAID enteropathy in the distal small bowel (ileum) is thought to be different than NSAID induced injury in the stomach and duodenum. | |||
**Enterohepatic recirculation (absorbed NSAID excreted via bile) is thought to play a role.<ref name=pmid21627632 >{{Cite journal | last1 = Wallace | first1 = JL. | title = NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. | journal = Br J Pharmacol | volume = 165 | issue = 1 | pages = 67-74 | month = Jan | year = 2012 | doi = 10.1111/j.1476-5381.2011.01509.x | PMID = 21627632 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Latest revision as of 17:08, 24 November 2016
NSAID enteropathy is inflammation of the small intestine due to a non-steroidal anti-inflammatory drug (NSAID).
General
- Clinical diagnosis.
- NSAID use - such as in rheumatoid arthritis or osteoarthritis.[1]
- The pathobiology of NSAID enteropathy in the distal small bowel (ileum) is thought to be different than NSAID induced injury in the stomach and duodenum.
- Enterohepatic recirculation (absorbed NSAID excreted via bile) is thought to play a role.[2]
Microscopic
- See Ileitis.
DDx:
References
- ↑ Tachecí, I.; Bradna, P.; Douda, T.; Baštecká, D.; Kopáčová, M.; Rejchrt, S.; Lutonský, M.; Soukup, T. et al. (Nov 2016). "Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis.". Rheumatol Int 36 (11): 1557-1561. doi:10.1007/s00296-016-3552-x. PMID 27549792.
- ↑ Wallace, JL. (Jan 2012). "NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies.". Br J Pharmacol 165 (1): 67-74. doi:10.1111/j.1476-5381.2011.01509.x. PMID 21627632.
- ↑ Dilauro, S.; Crum-Cianflone, NF. (Aug 2010). "Ileitis: when it is not Crohn's disease.". Curr Gastroenterol Rep 12 (4): 249-58. doi:10.1007/s11894-010-0112-5. PMID 20532706.