Difference between revisions of "Lymph nodes with isolated tumour cells"

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[[Category:Lymph nodes]]
[[Category:Lymph node pathology]]

Revision as of 12:56, 16 September 2016

Lymph nodes with isolated tumour cells, also isolated tumour cells and isolated cancer cells, is the presence of rare cancer cells in a lymph node.

General

Definition

  • An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm or <200 tumour cells.[1][2]

Significance

  • Not a significant predictor of outcome in breast pathology.[3]

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Right Breast, Modified Radical Mastectomy:
     - Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS 
	  (<100 tumour cells per lymph node).  
	-- All lymph nodes NEGATIVE for micrometatases and 
	   NEGATIVE for macrometatases (0/4).
     - Scar and therapy changes (hyalization, calcifications) compatible 
       with treated tumour.
     - Florid epithelial hyperplasia of the usual type.
     - Please see synoptic report.

Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.

See also

References

  1. ↑ Reed, J.; Rosman, M.; Verbanac, KM.; Mannie, A.; Cheng, Z.; Tafra, L. (Mar 2009). "Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study.". J Am Coll Surg 208 (3): 333-40. doi:10.1016/j.jamcollsurg.2008.10.036. PMID 19317993.
  2. ↑ Naidoo, K.; Pinder, SE. (Aug 2016). "Micro- and macro-metastasis in the axillary lymph node: A review.". Surgeon. doi:10.1016/j.surge.2016.07.002. PMID 27498412.
  3. ↑ Ahmed, SS.; Thike, AA.; Iqbal, J.; Yong, WS.; Tan, B.; Madhukumar, P.; Ong, KW.; Ho, GH. et al. (Mar 2014). "Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance.". J Clin Pathol 67 (3): 243-50. doi:10.1136/jclinpath-2013-201771. PMID 24218025.
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