Difference between revisions of "Giant cell arteritis"
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*The evidence is weak that the biopsy result influences management; a negative biopsy doesn't preclude treatment for clinically presumed giant cell arteritis.<ref name=pmid16287908>{{Cite journal | last1 = Lenton | first1 = J. | last2 = Donnelly | first2 = R. | last3 = Nash | first3 = JR. | title = Does temporal artery biopsy influence the management of temporal arteritis? | journal = QJM | volume = 99 | issue = 1 | pages = 33-6 | month = Jan | year = 2006 | doi = 10.1093/qjmed/hci141 | PMID = 16287908 }}</ref> | *The evidence is weak that the biopsy result influences management; a negative biopsy doesn't preclude treatment for clinically presumed giant cell arteritis.<ref name=pmid16287908>{{Cite journal | last1 = Lenton | first1 = J. | last2 = Donnelly | first2 = R. | last3 = Nash | first3 = JR. | title = Does temporal artery biopsy influence the management of temporal arteritis? | journal = QJM | volume = 99 | issue = 1 | pages = 33-6 | month = Jan | year = 2006 | doi = 10.1093/qjmed/hci141 | PMID = 16287908 }}</ref> | ||
===Minimal findings - positive=== | |||
<pre> | |||
Left Temporal Artery, Biopsy: | |||
- Medium size artery with a minimal lymphohistocytic inflammatory | |||
infiltrate, suggestive of temporal arteritis, see comment. | |||
COMMENT: | |||
The findings should be correlated with the clinical impression. The | |||
management should be dependent upon the clinical impression. | |||
</pre> | |||
===Negative with atherosclerosis=== | ===Negative with atherosclerosis=== | ||
Revision as of 13:50, 29 August 2016
| Giant cell arteritis | |
|---|---|
| Diagnosis in short | |
 Giant cell arteritis. H&E stain. | |
|
| |
| Synonyms | temporal arteritis |
|
| |
| LM | large artery with intramural inflammatory cells (often granulomatous); intimal thickening; frank destruction of arterial wall common - fibrinoid necrosis |
| Site | large blood vessels - see vasculitides |
|
| |
| Clinical history | typically older than 50 years |
| Signs | loss of vision, weight loss, chills, fever |
| Symptoms | jaw claudication (classic), headache (classic), double vision, scalp tenderness |
| Prevalence | uncommon |
| Blood work | ESR elevated |
| Prognosis | good if treated |
| Clin. DDx | other causes of headache |
| Treatment | steroids |
Giant cell arteritis (abbreviated GCA), also known as temporal arteritis, is a type of large vessel vasculitis.
General
- Classically afflicts the temporal artery.
Clinical features:
- Classic finding: jaw claudication, typically in a patient older than 50 years.
- Other findings: headache (very common),[1] vision loss or diplopia, scalp tenderness, polymyalgia, weight loss, chills, fever.
Work-up:
- CRP, ESR, temporal artery biopsy.
- ESR normal (>50 years old): <20 mm/hr males, <30 mm/hr females.[2]
Treatment:
- Treat right away with high dose steroids.
- Biopsy is confirmatory and is still diagnostic if done <7-10 days after treatment starts.[3]
Microscopic
Features - as per Le et al.:[1]
- Artery with intimal thickening.
- Transmural inflammatory cells.
- Giant cells.
Notes:
- Inflammation classically granulomatous.
- Granulomas not required for the diagnosis!
- Often accompanied by frank destruction of the arterial wall, e.g. fibrinoid necrosis (pink anucleate arterial wall).
Images
GCA - very low mag. (WC)
GCA - low mag. (WC)
GCA - intermed. mag. (WC)
GCA - high mag. (WC)
GCA - intermed mag. (WC)
GCA - high mag. (WC)
www:
DDx:
- Takayasu arteritis (can be overlapping with GCA)
- Aneurysm
- Amyloidosis
- Granulomatosis with polyangiitis (Wegener Granulomatosis)
- Polyarteritis nodosa
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Note:
- The evidence is weak that the biopsy result influences management; a negative biopsy doesn't preclude treatment for clinically presumed giant cell arteritis.[4]
Minimal findings - positive
Left Temporal Artery, Biopsy:
- Medium size artery with a minimal lymphohistocytic inflammatory
infiltrate, suggestive of temporal arteritis, see comment.
COMMENT:
The findings should be correlated with the clinical impression. The
management should be dependent upon the clinical impression.
Negative with atherosclerosis
Temporal Artery, Left, Biopsy: - Medium size artery with mild-to-moderate atherosclerosis, otherwise within normal limits, see comment. COMMENT: A negative biopsy does not rule out the possibility of giant cell (temporal) arteritis, as this may be a focal disorder. The clinical management is dependent upon the clinical impression.
Negative
Temporal Artery, Left, Biopsy: - Medium size artery without pathologic diagnosis, see comment. COMMENT: A negative biopsy does not rule out the possibility of giant cell (temporal) arteritis, as this may be a focal disorder. The clinical management is dependent upon the clinical impression.
Block letters
TEMPORAL ARTERY, LEFT, BIOPSY: - MEDIUM SIZE ARTERY WITHOUT PATHOLOGIC DIAGNOSIS, SEE COMMENT. COMMENT: A negative biopsy does not rule out the possibility of giant cell (temporal) arteritis, as this may be a focal disorder. The clinical management is dependent upon the clinical impression.
See also
References
- ↑ 1.0 1.1 Le, K.; Bools, LM.; Lynn, AB.; Clancy, TV.; Hooks, WB.; Hope, WW. (Oct 2014). "The effect of temporal artery biopsy on the treatment of temporal arteritis.". Am J Surg. doi:10.1016/j.amjsurg.2014.07.007. PMID 25457237.
- ↑ URL: http://www.nlm.nih.gov/medlineplus/ency/article/003638.htm. Accessed on: 17 August 2012.
- ↑ Weinberg, DA.; Savino, PJ.; Sergott, RC.; Bosley, TM. (Jul 1994). "Giant cell arteritis. Corticosteroids, temporal artery biopsy, and blindness.". Arch Fam Med 3 (7): 623-7. PMID 7921300.
- ↑ Lenton, J.; Donnelly, R.; Nash, JR. (Jan 2006). "Does temporal artery biopsy influence the management of temporal arteritis?". QJM 99 (1): 33-6. doi:10.1093/qjmed/hci141. PMID 16287908.