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Difference between revisions of "Lentigo simplex"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Skin_Tumors-171.jpg | |||
| Width = | |||
| Caption = Simple lentigo. [[H&E stain]]. (WC) | |||
| Synonyms = simple lentigo | |||
| Micro = melanocytes in epidermis only - hyperpigmentation; no melanocytic nests; +/-mild/moderate elongation of the rete ridges | |||
| Subtypes = | |||
| LMDDx = [[solar lentigo]], [[ephelis]] (freckle), melanotic macule, [[lentiginous nevus]], early [[seborrheic keratosis]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[skin]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usu. older than 40 years | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lentigo simplex''' is a common benign [[melanocytic lesion]]. | |||
It is also known as ''simple lentigo''.<ref>URL: [http://www.dermnetnz.org/lesions/lentigo-simplex.html http://www.dermnetnz.org/lesions/lentigo-simplex.html]. Accessed on: 27 March 2013.</ref> | |||
==General== | |||
*Benign. | |||
*Usually <40 years old. | |||
*May be precursor to [[seborrheic keratosis]].<ref name=pmid15729860>{{Cite journal | last1 = Sahin | first1 = MT. | last2 = Oztürkcan | first2 = S. | last3 = Ermertcan | first3 = AT. | last4 = Güneş | first4 = AT. | title = A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. | journal = J Dermatol | volume = 31 | issue = 11 | pages = 884-9 | month = Nov | year = 2004 | doi = | PMID = 15729860 }}</ref> | |||
Fits into the larger category of ''lentiginous melanocytic proliferations'' - these include:<ref name=Ref_Derm438>{{Ref Derm|438}}</ref> | |||
*[[Solar lentigo]]. | |||
*Lentigo simplex. | |||
*[[Lentiginous nevus]]. | |||
*Lentiginous [[melanoma in situ]]. | |||
Associated syndromes:<ref name=dermamin_ls>URL: [http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html]. Accessed on: 17 December 2012.</ref> | |||
*[[Peutz-Jeghers syndrome]]. | |||
*[[LEOPARD syndrome]]. | |||
*[[LAMB syndrome]]. | |||
==Gross== | |||
*Small flat pigmented lesion.<ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | |||
DDx - clinical: | |||
*[[Melanocytic nevus]].<ref name=pmid19536147>{{Cite journal | last1 = Hafner | first1 = C. | last2 = Stoehr | first2 = R. | last3 = van Oers | first3 = JM. | last4 = Zwarthoff | first4 = EC. | last5 = Hofstaedter | first5 = F. | last6 = Klein | first6 = C. | last7 = Landthaler | first7 = M. | last8 = Hartmann | first8 = A. | last9 = Vogt | first9 = T. | title = The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. | journal = J Invest Dermatol | volume = 129 | issue = 11 | pages = 2730-5 | month = Nov | year = 2009 | doi = 10.1038/jid.2009.146 | PMID = 19536147 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | |||
*Melanocytes in epidermis only. | |||
**Melanocytes basally located (normal location) with hyperpigmentation. | |||
*No melanocytic nests. | |||
*+/-Mild/moderate elongation of the rete ridges.<ref name=pmid19536147/> | |||
DDx:<ref name=humpath_ls/> | |||
*[[Solar lentigo]] - solar elastosis, usu. in sun exposed areas. | |||
*[[Ephelis]] (freckle) - change with UV light exposure. | |||
*Melanotic macule. | |||
*[[Lentiginous nevus]] - has melanocytic nests. | |||
*Early [[seborrheic keratosis]]. | |||
===Images=== | |||
*[http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html Lentigo simplex - several images (dermamin.com)].<ref name=dermamin_ls/> | |||
*[http://www.humpath.com/IMG/jpg/lentigo_simplex_20x.jpg Lentigo simplex (humpath.com)].<ref name=humpath_ls>URL: [http://www.humpath.com/?lentigo-simplex http://www.humpath.com/?lentigo-simplex]. Accessed on: 17 December 2012.</ref> | |||
<gallery> | |||
Image:Skin_Tumors-171.jpg | Simple lentigo. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
Left Hand Lesion, Radial, Biopsy: | |||
- Simple lentigo/early seborrheic keratosis. | |||
</pre> | |||
===Block letters=== | |||
<pre> | |||
SKIN LESION, LEFT ABDOMEN, BIOPSY: | |||
- SIMPLE LENTIGO, COMPLETELY EXCISED IN THE PLANE OF SECTION. | |||
</pre> | |||
<pre> | |||
SKIN LESION, LEFT ABDOMEN, BIOPSY: | |||
- BENIGN SIMPLE LENTIGO. | |||
</pre> | |||
===Micro=== | |||
The sections show skin with increased numbers of small pigmented melanocytes at the dermal-epidermal junction. The rete ridges are mildly elongated. No solar damage is apparent. No dermal melanocytes are identified. No melanocytic nests are identified. No nuclear atypia is apparent. | |||
==See also== | |||
*[[Melanocytic lesions]]. | |||
*[[Lentigo maligna]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||