Canalicular adenoma: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Canalicular_adenoma_--_high_mag.jpg | |||
| Width = | |||
| Caption = Canalicular adenoma. [[H&E stain]]. (WC) | |||
| Synonyms = | |||
| Micro = cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules, | |||
intraluminal squamous balls (common) | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[salivary gland]] - usually upper lip or buccal mucosa | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = mass lesion | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Canalicular adenoma''' is a rare [[salivary gland]] tumour. | '''Canalicular adenoma''' is a rare [[salivary gland]] tumour. | ||
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==Gross== | ==Gross== | ||
* | *Classically upper lip - may be buccal mucosa or palate. | ||
Note: | Note: | ||
*In one large series of 67 cases: | *In one large series of 67 cases:<ref name=pmid25141970/> | ||
**Upper lip 69% (47/67). | |||
**Buccal mucosa 25% (17/67). | |||
**Palate 6% (4/67). | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid25141970/> | ||
* | *Cords of tumour ("canals") with beading - characteristic. | ||
* | *Cystic spaces/tubules. | ||
*Intraluminal squamous balls - common (~60% of cases). | |||
*Myxoid/bluish stroma. | |||
DDx: | DDx: | ||
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===Images=== | ===Images=== | ||
*[http://www. | <gallery> | ||
*[http://www. | Image: Canalicular adenoma -- intermed mag.jpg | CA - intermed. mag. (WC) | ||
Image: Canalicular adenoma - alt -- intermed mag.jpg | CA - intermed. mag. (WC) | |||
Image: Canalicular adenoma -- high mag.jpg | CA - high mag. (WC) | |||
Image: Canalicular adenoma -- very high mag.jpg | CA - very high mag. (WC) | |||
Image: Canalicular adenoma - alt -- very high mag.jpg | CA - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig2/ CA (nih.gov)].<ref name=pmid25141970/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig3/ CA with myxoid stroma (nih.gov)]. | |||
==IHC== | ==IHC== | ||
*[[ | Features:<ref name=pmid25141970/> | ||
** | *[[S-100]] +ve - diffuse and strong. | ||
*[[Pankeratin]] +ve - diffuse and strong. | |||
*GFAP +ve - luminal. | |||
*SOX10 +ve - nuclear. | |||
*p16 +ve - luminal squamous balls. | |||
*CK5/6 +ve - luminal squamous balls. | |||
*p63 -ve. | |||
**Nuclei negative, cytoplasm positive. | |||
**Positive in basal cell adenoma. | |||
==See also== | ==See also== | ||