|
|
| (12 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| '''Renal transplant pathology''' is grouped with the ''[[medical kidney diseases]]'', as this one leads to the other, and many renal transplants have recurrence of the pathology that lead to renal failure. | | '''Renal transplant pathology''', also '''kidney tranplant pathology''', is grouped with the ''[[medical kidney diseases]]'', as this usually precedes the transplant. Also, many renal transplants have recurrence of the pathology that lead to renal failure. |
|
| |
|
| =Rejection= | | =Rejection= |
| Line 83: |
Line 83: |
| =Infection= | | =Infection= |
| ==Polyomavirus nephropathy== | | ==Polyomavirus nephropathy== |
| :See also: ''[[Urine_cytopathology#Human_polyoma_infection]]'' and ''[[Polyomavirus]]''. | | :See also: ''[[Urine_cytopathology#Human_polyomavirus_infection]]'' and ''[[Polyomavirus]]''. |
| ===General===
| | {{Main|Polyomavirus nephropathy}} |
| *This bad-boy is associated with failure of transplanted kidneys.<ref name=pmid216990>{{cite journal |author=Mackenzie EF, Poulding JM, Harrison PR, Amer B |title=Human polyoma virus (HPV)--a significant pathogen in renal transplantation |journal=Proc Eur Dial Transplant Assoc |volume=15 |issue= |pages=352–60 |year=1978 |pmid=216990 |doi= |url=}}</ref>
| |
| *Treatment: reduce immunosuppression.<ref name=Nickeleit>Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539]. Accessed on: 8 November 2010.</ref>
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Nickeleit/>
| |
| *Ground glass-like nuclear inclusions.
| |
| *Nuclear enlargement.
| |
| | |
| Images:
| |
| *www:
| |
| **[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>
| |
| **[http://path.upmc.edu/cases/case582.html Polyomavirus nephropathy - several images (upmc.edu)].
| |
| *[[WC]]:
| |
| **[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_high_mag.jpg PN - high mag. (WC)].
| |
| **[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_very_high_mag.jpg PN - very high mag. (WC)].
| |
| | |
| ===IHC===
| |
| Features:
| |
| *SV40 +ve (nuclear staining).
| |
| | |
| Images:
| |
| *www:
| |
| **[http://tpis1.upmc.com:81/tpis/GU/G00011b.html Polyomavirus (upmc.com)].
| |
| *[[WC]]:
| |
| **[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_sv40_-_high_mag.jpg PN - high mag. (WC)].
| |
| **[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_sv40_-_very_high_mag.jpg PN - very high mag. (WC)].
| |
|
| |
|
| =Transplant-related pathology= | | =Transplant-related pathology= |
| Line 129: |
Line 103: |
| *[[MPGN]] (hepatitis C). | | *[[MPGN]] (hepatitis C). |
| *[[Thrombotic microangiopathy]] (TMA). | | *[[Thrombotic microangiopathy]] (TMA). |
| | |
| | ====Images==== |
| | <gallery> |
| | Image:Transplant_glomerulopathy_-_intermed_mag.jpg | Transplant glomerulopathy - intermed. mag. (WC/Nephron) |
| | Image:Transplant_glomerulopathy_-_high_mag.jpg | Transplant glomerulopathy - high mag. (WC/Nephron) |
| | Image:Transplant_glomerulopathy_-_very_high_mag.jpg | Transplant glomerulopathy - very high mag. (WC/Nephron) |
| | </gallery> |
|
| |
|
| ==Chronic allograft nephropathy== | | ==Chronic allograft nephropathy== |
| Line 145: |
Line 126: |
| *Interstitial fibrosis and renal tubular atrophy. | | *Interstitial fibrosis and renal tubular atrophy. |
|
| |
|
| Image: | | ===Images=== |
| *[http://commons.wikimedia.org/wiki/File:Chronic_allograft_nephropathy_-_intermed_mag.jpg CAN - intermed. mag. (WC)].
| | <gallery> |
| | Image:Chronic_allograft_nephropathy_-_intermed_mag.jpg | CAN - intermed. mag. (WC/Nephron) |
| | </gallery> |
|
| |
|
| ==Calcineurin-inhibitor toxicity== | | ==Calcineurin-inhibitor toxicity== |