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Sclerosing adenosis of the breast (view source)
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'''Sclerosing adenosis of the breast''', also '''sclerosing adenosis''', a benign pathology of the breast associated with an increased risk of malignancy. | |||
==General== | |||
*Can be scary... can look like [[ductal carcinoma]]. | |||
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement). | |||
**Think ''scaring'' + ''lotsa glands'' and you're pretty close. | |||
*Management: follow-up, no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</ref> | |||
==Microscopic== | |||
Features: | |||
*Acini are smaller than usual and there are more of them. | |||
**Acini often slit-like. | |||
*Fibrosis (scleroses) - pink on H&E surrounds the acini. | |||
**Can mimic a [[desmoplastic reaction]]. | |||
Notes: | |||
*The acini should: | |||
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''. | |||
**Have two cell layers like well-behaved breast glands do. | |||
DDx: | |||
*Low-grade [[Invasive ductal carcinoma of the breast|ductal carcinoma]]. | |||
*[[Tubular adenoma of the breast]]. | |||
*[[Adenomyoepithelioma]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref> | |||
*Breast adenosis - should have visble lumens. | |||
==See also== | |||
*[[Breast pathology]]. | |||
*[[Sclerosing adenosis]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||
[[Category:Breast pathology]] | |||