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Difference between revisions of "Intratumoural lymphocytic response in colorectal carcinoma"
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Intratumoural lymphocytic response in colorectal carcinoma (view source)
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[[Image:Tumour-infiltrating lymphocytes - 2 -- very high mag.jpg|thumb|right|Intratumoural lymphocytic response in colorectal carcinoma in | [[Image:Tumour-infiltrating lymphocytes - 2 -- very high mag.jpg|thumb|right|Intratumoural lymphocytic response in colorectal carcinoma, as may be seen in [[Microsatellite instability in colorectal cancer|microsatellite instability]]. [[H&E stain]]. (WC)]] | ||
This article deals with '''intratumoural lymphocytic response in colorectal carcinoma'''. It is usually | This article deals with the '''intratumoural lymphocytic response in colorectal carcinoma'''. It is usually referred to as '''intratumoural lymphocytic response'''. | ||
It is also known as '''tumour-infiltrating lymphocytes''', abbreviated '''TILs'''. | It is also known as '''tumour-infiltrating lymphocytes''', abbreviated '''TILs'''. | ||
A general discussion about TILs is in the ''[[tumour-infiltrating lymphocytes]]'' article. | |||
==General== | ==General== | ||
*Finding is suggestive of microsatellite | *Finding is suggestive of [[Microsatellite instability in colorectal cancer|microsatellite instability]].<ref name=pmid21114775>{{Cite journal | last1 = Iacopetta | first1 = B. | last2 = Grieu | first2 = F. | last3 = Amanuel | first3 = B. | title = Microsatellite instability in colorectal cancer. | journal = Asia Pac J Clin Oncol | volume = 6 | issue = 4 | pages = 260-9 | month = Dec | year = 2010 | doi = 10.1111/j.1743-7563.2010.01335.x | PMID = 21114775 }}</ref> | ||
**May be seen in the context of [[Lynch syndrome]]. | **May be seen in the context of [[Lynch syndrome]]. | ||
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**Lymphocytes must be between the tumour cells.<ref name=pmid12717242/><ref name=pmid19638537/> †† | **Lymphocytes must be between the tumour cells.<ref name=pmid12717242/><ref name=pmid19638537/> †† | ||
***Lymphocytes elsewhere, e.g. in the peritumoural stroma, do ''not'' count. | ***Lymphocytes elsewhere, e.g. in the peritumoural stroma, do ''not'' count. | ||
***Typically, the lymphocytes have a halo around them. | |||
Notes: | |||
* † Greenson ''et al.'' says ''>2 lymphocytes/HPF, where 5 HPF are sampled''. Since the sample area given by Greenson ''et al.'' is 0.94 mm<sup>2</sup>, | * † Greenson ''et al.'' says ''>2 lymphocytes/HPF, where 5 HPF are sampled with the 40x objective''. Since the sample area given by Greenson ''et al.'' is 0.94 mm<sup>2</sup>, the field diameter is ~ 0.4892 mm. This field diameter corresponds to a 20 mm eye piece (0.4892 mm * 40x = 19.57 mm). | ||
**Many microscopes in use today have a field diameter at 40x of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm<sup>2</sup>. | **Many microscopes in use today have a field diameter (at 40x) of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm<sup>2</sup>. | ||
* †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".<reF name=pmid9349235>{{Cite journal | last1 = Ropponen | first1 = KM. | last2 = Eskelinen | first2 = MJ. | last3 = Lipponen | first3 = PK. | last4 = Alhava | first4 = E. | last5 = Kosma | first5 = VM. | title = Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. | journal = J Pathol | volume = 182 | issue = 3 | pages = 318-24 | month = Jul | year = 1997 | doi = 10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6 | PMID = 9349235 |URL = http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291096-9896%28199707%29182:3%3C318::AID-PATH862%3E3.0.CO;2-6/pdf}}</ref> | * †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".<reF name=pmid9349235>{{Cite journal | last1 = Ropponen | first1 = KM. | last2 = Eskelinen | first2 = MJ. | last3 = Lipponen | first3 = PK. | last4 = Alhava | first4 = E. | last5 = Kosma | first5 = VM. | title = Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. | journal = J Pathol | volume = 182 | issue = 3 | pages = 318-24 | month = Jul | year = 1997 | doi = 10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6 | PMID = 9349235 |URL = http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291096-9896%28199707%29182:3%3C318::AID-PATH862%3E3.0.CO;2-6/pdf}}</ref> | ||
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==See also== | ==See also== | ||
*[[Colorectal adenocarcinoma]]. | *[[Colorectal adenocarcinoma]]. | ||
*[[Crohn's like response | *[[Peritumoural lymphocytic response]] - also known as ''Crohn's like response''. | ||
==References== | ==References== | ||