Difference between revisions of "Nucleus-to-cytoplasm ratio"
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[[Image:Small_cell_lung_cancer_-_cytology.jpg|thumb|200px|Cells with a high NC ratio ([[small cell carcinoma]]).]] | |||
'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | '''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | ||
High NC ratio is strong predictor of malignancy.<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | High NC ratio is a strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | ||
</ref> Like very rule, there are exceptions. | </ref> Like very rule, there are exceptions. | ||
NC ratio is a better predictor of malignancy than increased nuclear size. | |||
===High NC ratio in normal cells=== | ===High NC ratio in normal cells=== | ||
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===High NC ratio in cancer=== | ===High NC ratio in cancer=== | ||
The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the ''[[small round cell tumour]]'' group. | The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the large ''[[small round cell tumour]]'' group. | ||
*Many other tumours. | *Many other tumours - see ''[[A long differential diagnosis of small blue cell tumours]]''. | ||
*Preoperative treatment may increase NC ratio - example: pituitary adenoma under bromocriptine treatment.<ref>{{Cite journal | last1 = Nissim | first1 = M. | last2 = Ambrosi | first2 = B. | last3 = Bernasconi | first3 = V. | last4 = Giannattasio | first4 = G. | last5 = Giovanelli | first5 = MA. | last6 = Bassetti | first6 = M. | last7 = Vaccari | first7 = U. | last8 = Moriondo | first8 = P. | last9 = Spada | first9 = A. | title = Bromocriptine treatment of macroprolactinomas: studies on the time course of tumor shrinkage and morphology. | journal = J Endocrinol Invest | volume = 5 | issue = 6 | pages = 409-15 | month = | year = | doi = 10.1007/BF03350542 | PMID = 7169515 }}</ref> | |||
===Atypical cells with a normal NC ratio=== | |||
*[[Radiation changes]] - [[clinical history]] is important! | |||
*Many tumours. | |||
==See also== | ==See also== | ||
*[[Nuclear pleomorphism]]. | *[[Nuclear pleomorphism]]. | ||
*[[Nuclear atypia]]. | |||
*[[Basics]]. | *[[Basics]]. | ||
*[[Cytologic features and malignancy]]. | *[[Cytologic features and malignancy]]. | ||
Latest revision as of 06:23, 19 May 2016
Cells with a high NC ratio (small cell carcinoma).
Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.
High NC ratio is a strong predictor of malignancy.[1] Like very rule, there are exceptions.
NC ratio is a better predictor of malignancy than increased nuclear size.
High NC ratio in normal cells
- Lymphocytes.
Low NC ratio in cancer
- Fibrolamellar hepatocellular carcinoma.
- Acinic cell carcinoma.
- Many others.
High NC ratio in cancer
The classic malignant high NC ratio cell is small cell carcinoma, which is in the large small round cell tumour group.
- Many other tumours - see A long differential diagnosis of small blue cell tumours.
- Preoperative treatment may increase NC ratio - example: pituitary adenoma under bromocriptine treatment.[2]
Atypical cells with a normal NC ratio
- Radiation changes - clinical history is important!
- Many tumours.
See also
References
- ↑ Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.
- ↑ Nissim, M.; Ambrosi, B.; Bernasconi, V.; Giannattasio, G.; Giovanelli, MA.; Bassetti, M.; Vaccari, U.; Moriondo, P. et al. "Bromocriptine treatment of macroprolactinomas: studies on the time course of tumor shrinkage and morphology.". J Endocrinol Invest 5 (6): 409-15. doi:10.1007/BF03350542. PMID 7169515.