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Difference between revisions of "Lymphocytic interstitial pneumonia"
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Lymphocytic interstitial pneumonia (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Lymphocytic interstitial pneumonia -- intermed mag.jpg | |||
| Width = | |||
| Caption = Lymphocytic interstitial pneumonia. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small mature lymphocytes in the interstitium of the lung, plasma cells, +/-lymphoid follicles | |||
| Subtypes = | |||
| LMDDx = [[lymphoma]] - see ''[[lymphoma of lung]]'', [[follicular bronchitis/bronchiolitis]], [[pulmonary nodular lymphoid hyperplasia|nodular lymphoid hyperplasia]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[lung]] - see ''[[diffuse lung diseases]]'' | |||
| Assdx = autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]]), viral infections ([[HIV]], [[EBV]], human T-cell leukemia virus (HTLV) type 1) | |||
| Syndromes = | |||
| Clinicalhx = dependent on underlying cause - see ''associated diagnoses'' | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = basilar predominance, increased interstitial markings | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lymphocytic interstitial pneumonia''' (abbreviated '''LIP'''), also known as '''lymphoid interstitial pneumonia''' and '''lymphocytic interstitial pneumonitis''', is an uncommon [[diffuse lung disease]]. | '''Lymphocytic interstitial pneumonia''' (abbreviated '''LIP'''), also known as '''lymphoid interstitial pneumonia''' and '''lymphocytic interstitial pneumonitis''', is an uncommon [[diffuse lung disease]]. | ||
==General== | ==General== | ||
*Associated with autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]])<ref>URL: [http://emedicine.medscape.com/article/299643-overview http://emedicine.medscape.com/article/299643-overview]. Accessed on: 2 June 2010.</ref> and immunodeficiency.<ref name=pmid16088689>{{cite journal |author=Nicholson AG |title=Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung |journal=Semin Respir Crit Care Med |volume=22 |issue=4 |pages=409–22 |year=2001 |month=August |pmid=16088689 |doi=10.1055/s-2001-17384 |url=}}</ref> | *Associated with autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]])<ref>URL: [http://emedicine.medscape.com/article/299643-overview http://emedicine.medscape.com/article/299643-overview]. Accessed on: 2 June 2010.</ref> and immunodeficiency.<ref name=pmid16088689>{{cite journal |author=Nicholson AG |title=Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung |journal=Semin Respir Crit Care Med |volume=22 |issue=4 |pages=409–22 |year=2001 |month=August |pmid=16088689 |doi=10.1055/s-2001-17384 |url=}}</ref> | ||
*Associated with viral infections ([[HIV]], EBV, human T-cell leukemia virus (HTLV) type 1). | *Associated with viral infections ([[HIV]], [[EBV]], human T-cell leukemia virus (HTLV) type 1). | ||
**Considered an AIDS-defining diagnosis.<ref>{{Cite journal | last1 = Turner | first1 = BJ. | last2 = Eppes | first2 = S. | last3 = McKee | first3 = LJ. | last4 = Cosler | first4 = L. | last5 = Markson | first5 = LE. | title = A population-based comparison of the clinical course of children and adults with AIDS. | journal = AIDS | volume = 9 | issue = 1 | pages = 65-72 | month = Jan | year = 1995 | doi = | PMID = 7893443 }}</ref> | **Considered an AIDS-defining diagnosis.<ref name=pmid7893443>{{Cite journal | last1 = Turner | first1 = BJ. | last2 = Eppes | first2 = S. | last3 = McKee | first3 = LJ. | last4 = Cosler | first4 = L. | last5 = Markson | first5 = LE. | title = A population-based comparison of the clinical course of children and adults with AIDS. | journal = AIDS | volume = 9 | issue = 1 | pages = 65-72 | month = Jan | year = 1995 | doi = | PMID = 7893443 }}</ref> | ||
==Gross== | ==Gross== | ||
| Line 22: | Line 54: | ||
DDx: | DDx: | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*Follicular bronchitis/bronchiolitis. | *[[Follicular bronchitis/bronchiolitis]]. | ||
*Nodular lymphoid hyperplasia. | *[[Pulmonary nodular lymphoid hyperplasia|Nodular lymphoid hyperplasia]]. | ||
**This is determined in part by radiology; it has nodules radiographically. | **This is determined in part by radiology; it has nodules radiographically. | ||
*[[Non-specific interstitial pneumonia]] - less inflammation. | |||
===Images=== | ===Images=== | ||
www | ====Case==== | ||
<gallery> | |||
Image: Lymphocytic interstitial pneumonia -- extremely low mag.jpg | LIP - ext. low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia -- very low mag.jpg | LIP - very low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia -- low mag.jpg | LIP - low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia -- intermed mag.jpg | LIP - intermed. mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia -- high mag.jpg | LIP - high mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia -- very high mag.jpg | LIP - very high mag. (WC/Nephron) | |||
<gallery/> | |||
<gallery> | |||
Image: Lymphocytic interstitial pneumonia and normal -- very low mag.jpg | LIP & normal - very low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia and normal -- low mag.jpg | LIP & normal - low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia and normal - alt -- low mag.jpg | LIP & normal - low mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia and normal -- intermed mag.jpg | LIP & normal - intermed mag. (WC/Nephron) | |||
Image: Lymphocytic interstitial pneumonia and normal -- high mag.jpg | LIP & normal - high mag. (WC/Nephron) | |||
</gallery> | |||
====www==== | |||
*[http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | *[http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | ||
*[http://path.upmc.edu/cases/case176/micro.html LIP (upmc.edu)]. | *[http://path.upmc.edu/cases/case176/micro.html LIP (upmc.edu)]. | ||