Difference between revisions of "Desquamative interstitial pneumonia"

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| Caption    =  
| Caption    =  
| Synonyms  =
| Synonyms  =
| Micro      =
| Micro      = abundant brown pigmented airspace macrophages (smoker's macrophages), architecture preserved ("linear fibrosis")
| Subtypes  =
| Subtypes  =
| LMDDx      = amiodarone toxicity, fibrotic [[NSIP]], [[RBILD]]
| LMDDx      = amiodarone toxicity, fibrotic [[NSIP]], [[RBILD]]
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[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Diffuse lung diseases]]

Revision as of 04:10, 21 March 2016

Desquamative interstitial pneumonia
Diagnosis in short

LM abundant brown pigmented airspace macrophages (smoker's macrophages), architecture preserved ("linear fibrosis")
LM DDx amiodarone toxicity, fibrotic NSIP, RBILD
Site lung - see diffuse lung diseases

Associated Dx smoking
Prevalence uncommon
Treatment stop smoking

Desquamative interstitial pneumonia, abbreviated DIP, is a diffuse lung disease that is strongly associated with smoking.

General

  • Thought to be advanced RBILD.
  • Strong association with smoking.[1]
    • Treatment: stop smoking.

Microscopic

Features:

  • Abundant brown pigmented airspace macrophages - smoker's macrophages - key feature.
  • Architecture preserved; "linear fibrosis".

Notes:

  • Some fields of view may be indistinguishable from RBILD.

DDx:

Images

Stains

  • Macrophages PAS +ve.

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 93. ISBN 978-0781765275.