Difference between revisions of "Desquamative interstitial pneumonia"

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'''Desquamative interstitial pneumonia''', abbreviated ''DIP'', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      = amiodarone toxicity, fibrotic [[NSIP]], [[RBILD]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[lung]] - see ''[[diffuse lung diseases]]''
| Assdx      = [[smoking]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        = stop smoking
}}
'''Desquamative interstitial pneumonia''', abbreviated '''DIP''', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]].


==General==
==General==
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*Amiodarone toxicity.
*Amiodarone toxicity.
*Fibrotic [[NSIP]].
*Fibrotic [[NSIP]].
*[[RBILD]].


Images:
===Images===
*[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)].
*[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)].



Revision as of 04:08, 21 March 2016

Desquamative interstitial pneumonia
Diagnosis in short
LM DDx amiodarone toxicity, fibrotic NSIP, RBILD
Site lung - see diffuse lung diseases

Associated Dx smoking
Prevalence uncommon
Treatment stop smoking

Desquamative interstitial pneumonia, abbreviated DIP, is a diffuse lung disease that is strongly associated with smoking.

General

  • Thought to be advanced RBILD.
  • Strong association with smoking.[1]
    • Treatment: stop smoking.

Microscopic

Features:

  • Abundant brown pigmented airspace macrophages - smoker's macrophages - key feature.
  • Architecture preserved; "linear fibrosis".

Notes:

  • Some fields of view may be indistinguishable from RBILD.

DDx:

Images

Stains

  • Macrophages PAS +ve.

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 93. ISBN 978-0781765275.