Difference between revisions of "Succinate dehydrogenase"

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[[Image:Denervation atrophy - sdh - very high mag.jpg|thumb|right|SDH immunostain in a muscle biopsy with denervation atrophy.]]
'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain.  It is localized to the mitochondria.
'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain.  It is localized to the mitochondria.


Mutation-associated with pathology:
==Immunostain==
*It is used to look for mitochondrial disease.
*Loss of staining is pathologic.
 
==Associated pathology==
Mutations in SDH genes are associated with:
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal  | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref>
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal  | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref>
*[[Pheochromocytoma]].<ref name=pmid24500761/>
*[[Pheochromocytoma]].<ref name=pmid24500761/>
*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal  | last1 = Ricketts | first1 = CJ. | last2 = Shuch | first2 = B. | last3 = Vocke | first3 = CD. | last4 = Metwalli | first4 = AR. | last5 = Bratslavsky | first5 = G. | last6 = Middelton | first6 = L. | last7 = Yang | first7 = Y. | last8 = Wei | first8 = MH. | last9 = Pautler | first9 = SE. | title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. | journal = J Urol | volume = 188 | issue = 6 | pages = 2063-71 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.08.030 | PMID = 23083876 }}</ref>
*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal  | last1 = Ricketts | first1 = CJ. | last2 = Shuch | first2 = B. | last3 = Vocke | first3 = CD. | last4 = Metwalli | first4 = AR. | last5 = Bratslavsky | first5 = G. | last6 = Middelton | first6 = L. | last7 = Yang | first7 = Y. | last8 = Wei | first8 = MH. | last9 = Pautler | first9 = SE. | title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. | journal = J Urol | volume = 188 | issue = 6 | pages = 2063-71 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.08.030 | PMID = 23083876 }}</ref>
*[[Gastrointestinal stromal tumour]].


==See also==
==See also==
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
*[[Neuromuscular pathology]].
*[[Neuromuscular pathology]].
*[[Carney-Stratakis syndrome]].


==References==
==References==
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[[Category:Immunohistochemistry]]
[[Category:Immunohistochemistry]]
[[Category:Molecular pathology]]

Latest revision as of 15:18, 15 March 2016

SDH immunostain in a muscle biopsy with denervation atrophy.

Succinate dehydrogenase, abbreviated SDH, is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Immunostain

  • It is used to look for mitochondrial disease.
  • Loss of staining is pathologic.

Associated pathology

Mutations in SDH genes are associated with:

See also

References

  1. 1.0 1.1 Vicha, A.; Taieb, D.; Pacak, K. (Jun 2014). "Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.". Endocr Relat Cancer 21 (3): R261-77. doi:10.1530/ERC-13-0398. PMID 24500761.
  2. Ricketts, CJ.; Shuch, B.; Vocke, CD.; Metwalli, AR.; Bratslavsky, G.; Middelton, L.; Yang, Y.; Wei, MH. et al. (Dec 2012). "Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.". J Urol 188 (6): 2063-71. doi:10.1016/j.juro.2012.08.030. PMID 23083876.