Difference between revisions of "Spindle cell"
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[[Image:Malignant peripheral nerve sheath tumour - very high mag.jpg | thumb| right| Spindle cells in a [[MPNST]]. ([[WC]])]] | |||
[[Image:Cutaneous leiomyosarcoma - high mag.jpg | thumb |right| Spindle cells in a [[leiomyosarcoma]]. (WC)]] | |||
'''Spindle cell''' is a histomorphologic descriptor used in [[pathology]]. | '''Spindle cell''' is a histomorphologic descriptor used in [[pathology]]. | ||
A list of spindle cell lesions is found the in the ''[[spindle cell lesions]]'' article. | |||
==Definition== | ==Definition== | ||
It refers to a cell that is tapered at both ends.<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=25657 http://www.medterms.com/script/main/art.asp?articlekey=25657]. Accessed on: 2 February 2011.</ref> | It refers to a cell that is tapered at both ends.<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=25657 http://www.medterms.com/script/main/art.asp?articlekey=25657]. Accessed on: 2 February 2011.</ref> | ||
Notes: | Notes: | ||
*A taper | *A taper ''gradually decreases toward one end <nowiki>[of the cross-section or width]</nowiki>''.<ref>URL: [http://dictionary.reference.com/browse/taper http://dictionary.reference.com/browse/taper]. Accessed on: 3 February 2011.</ref> | ||
**Image: [http://qcfocus.com/files/Pipe%20Thread%20Taper.jpg Taperred thread (qcfocus.com)]. | **Image: [http://qcfocus.com/files/Pipe%20Thread%20Taper.jpg Taperred thread (qcfocus.com)]. | ||
*Spindle cells can have "pointy" ends or "rounded" ends, i.e. be ellipitcal or vesica piscis. | *Spindle cells can have "pointy" ends (typical for nerves) or "rounded" ends (typical for muscle), i.e. be ellipitcal or vesica piscis. | ||
===Subtyping spindle cells by H&E=== | |||
Spindle cells can often be subtyped based on H&E:<ref name=pmid24406626>{{Cite journal | last1 = Chan | first1 = JK. | title = The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology. | journal = Int J Surg Pathol | volume = 22 | issue = 1 | pages = 12-32 | month = Feb | year = 2014 | doi = 10.1177/1066896913517939 | PMID = 24406626 }}</ref> | |||
*Fibroblast = blue. | |||
*Smooth muscle = deep pink. | |||
*Myofibroblast = purple. | |||
===Images=== | |||
<gallery> | |||
Image:Spindle_neurons_-_very_high_mag_-_cropped.jpg | Spindle neurons. (WC) | |||
Image:Urinary bladder muscularis mucosae -- very high mag.jpg | Benign smooth muscle cells of the [[urinary bladder]]. (WC) | |||
Image:Schwannoma_-_Antoni_A_and_B_-_very_high_mag.jpg | Spindle cells of a schwannoma. (WC) | |||
</gallery> | |||
====Shapes==== | |||
<gallery> | |||
Image:Drop spindle from Egypt.jpg | A spindle. (WC) | |||
Image:Vesica Piscis.svg | Vesica piscis. (WC) | |||
Image:Ellipse parameters 2.svg | Ellipse. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
Latest revision as of 13:43, 25 February 2016
Spindle cells in a leiomyosarcoma. (WC)
Spindle cell is a histomorphologic descriptor used in pathology.
A list of spindle cell lesions is found the in the spindle cell lesions article.
Definition
It refers to a cell that is tapered at both ends.[1]
Notes:
- A taper gradually decreases toward one end [of the cross-section or width].[2]
- Image: Taperred thread (qcfocus.com).
- Spindle cells can have "pointy" ends (typical for nerves) or "rounded" ends (typical for muscle), i.e. be ellipitcal or vesica piscis.
Subtyping spindle cells by H&E
Spindle cells can often be subtyped based on H&E:[3]
- Fibroblast = blue.
- Smooth muscle = deep pink.
- Myofibroblast = purple.
Images
Spindle neurons. (WC)
Benign smooth muscle cells of the urinary bladder. (WC)
Spindle cells of a schwannoma. (WC)
Shapes
A spindle. (WC)
Vesica piscis. (WC)
Ellipse. (WC)
See also
References
- ↑ URL: http://www.medterms.com/script/main/art.asp?articlekey=25657. Accessed on: 2 February 2011.
- ↑ URL: http://dictionary.reference.com/browse/taper. Accessed on: 3 February 2011.
- ↑ Chan, JK. (Feb 2014). "The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.". Int J Surg Pathol 22 (1): 12-32. doi:10.1177/1066896913517939. PMID 24406626.