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Difference between revisions of "Retinoblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Rtbl400.GIF | |||
| Width = | |||
| Caption = Retinoblastoma. (WC) | |||
| Synonyms = | |||
| Micro = [[small round cell tumour]], Flexner-Wintersteiner [[rosette]]s, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications | |||
| Subtypes = | |||
| LMDDx = retinocytoma, other [[small round cell tumours]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = white, solid, friable | |||
| Grossing = | |||
| Staging = | |||
| Site = [[eye]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Retinoblastoma''' is a malignant tumour the of the [[eye]]. | |||
==General== | |||
*Rare. | |||
*[[Malignant]]. | |||
*May be familial.<ref name=pmid20687510>{{cite journal |author=Lohmann D |title=Retinoblastoma |journal=Adv. Exp. Med. Biol. |volume=685 |issue= |pages=220–7 |year=2010 |pmid=20687510 |doi= |url=}}</ref> | |||
==Gross== | |||
*White, solid. | |||
*Patterns: | |||
**Endophytic - grow into the vitreous cavity. | |||
**Exophytic - grow toward choroid. | |||
**Mixed - components of endophytic and exophytic. | |||
Note: | |||
*Tumour is extremely friable. | |||
===Image=== | |||
*[http://radiopaedia.org/cases/retinoblastoma-gross-pathology Retinoblastoma (radiopaedia.org/AFIP)]. | |||
==Microscopic== | |||
Features: | |||
*[[Small round cell tumour]]: | |||
**Scant cytoplasm. | |||
*Flexner-Wintersteiner [[rosette]] - '''key feature'''. | |||
**Rosette with empty centre (donut hole).<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | |||
*+/-Homer-Wright rosette.<ref>WH. 14 March 2011.</ref> | |||
**Circular rosette with neuropil at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | |||
*Mitoses - common. | |||
*+/-Necrosis. | |||
*+/-Calcification. | |||
DDx: | |||
*Retinocytoma (retinoma) - benign counterpart of retinoblastoma. | |||
Notes: | |||
*DDx of Flexner-Wintersteiner rosette includes: | |||
**Pineoblastoma. | |||
**Medulloepithelioma. | |||
===Images=== | |||
<gallery> | |||
Image:Rtbl400.GIF | Retinoblastoma. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)]. | |||
*[http://www.pathpedia.com/Education/eAtlas/Histopathology/eye_and_ocular_adnexa/retinoblastoma.aspx Retinoblastoma (pathpedia.com)]. | |||
==See also== | |||
*[[Eye]]. | |||
*[[Small round cell tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Eye]] | |||