Difference between revisions of "Adenoid cystic/basal cell carcinoma of the prostate"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Adenoid cystic basal cell carcinoma of the prostate -- intermed mag.jpg
| Width      =
| Caption    = Adenoid cystic/basal cell carcinoma of the prostate. [[H&E stain]].
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      = adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]]
| Stains    =
| IHC        = BCLA2 +ve, Ki-67 >20, HER2 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usually good
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Adenoid cystic/basal cell carcinoma of the prostate''', abbreviated '''ACBCC''', is a rare from of [[prostate cancer]] that resembles [[adenoid cystic carcinoma]] and [[basal cell carcinoma]].
'''Adenoid cystic/basal cell carcinoma of the prostate''', abbreviated '''ACBCC''', is a rare from of [[prostate cancer]] that resembles [[adenoid cystic carcinoma]] and [[basal cell carcinoma]].
It is also known as '''adenoid cystic carcinoma of the prostate'''.<ref name=pmid15371944/>


==General==
==General==
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**Nests of cells that have round spaces filled by whispy blue mucin.
**Nests of cells that have round spaces filled by whispy blue mucin.
**Dense collagenous stroma.
**Dense collagenous stroma.
DDx:
*Adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]]<ref name=pmid15371944>{{Cite journal  | last1 = McKenney | first1 = JK. | last2 = Amin | first2 = MB. | last3 = Srigley | first3 = JR. | last4 = Jimenez | first4 = RE. | last5 = Ro | first5 = JY. | last6 = Grignon | first6 = DJ. | last7 = Young | first7 = RH. | title = Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification. | journal = Am J Surg Pathol | volume = 28 | issue = 10 | pages = 1289-98 | month = Oct | year = 2004 | doi =  | PMID = 15371944 }}</ref> - BCL2 -ve, Ki-67 low.<ref name=pmid9865831/>


===Images===
===Images===
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*[http://www.webpathology.com/image.asp?case=23&n=16 Adenoid basal cell tumour (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=23&n=16 Adenoid basal cell tumour (webpathology.com)].
-->
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==IHC==
==IHC==
*HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal  | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref>
*HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal  | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref>
 
*CK34betaE12 +ve ([[Adenoid cystic carcinoma|AdCC]] component).<ref name=pmid15371944/>
*BCL2 +ve.<ref name=pmid9865831>{{Cite journal  | last1 = Yang | first1 = XJ. | last2 = McEntee | first2 = M. | last3 = Epstein | first3 = JI. | title = Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67. | journal = Hum Pathol | volume = 29 | issue = 12 | pages = 1447-50 | month = Dec | year = 1998 | doi =  | PMID = 9865831 }}</ref>
*Ki-67 >20%.<ref name=pmid9865831/>
==See also==
==See also==
*[[Prostate cancer]].
*[[Prostate cancer]].
*[[Adenoid cystic carcinoma]].
*[[Basal cell carcinoma]].


==References==
==References==
48,975

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