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Difference between revisions of "Sarcomatoid carcinoma of the prostate"
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Sarcomatoid carcinoma of the prostate (view source)
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'''Sarcomatoid prostate carcinoma''' is a rare subtype of [[prostatic carcinoma]] | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Sarcomatoid_prostate_carcinoma_-_alt_--_intermed_mag.jpg | |||
| Width = | |||
| Caption = Sarcomatoid carcinoma of the prostate. [[H&E stain]]. | |||
| Synonyms = sarcomatoid prostatic carcinoma | |||
| Micro = | |||
| Subtypes = (subtype of [[prostate carcinoma]]) | |||
| LMDDx = [[sarcoma]], [[sarcomatoid urothelial carcinoma]] | |||
| Stains = | |||
| IHC = PSA +ve, keratin +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]] | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate carcinoma]]'' | |||
| Assdx = | |||
| Syndromes = see ''[[prostate carcinoma]]'' | |||
| Clinicalhx = typically have history of conventional prostate carcinoma | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = see ''[[prostate carcinoma]]'' | |||
| Tx = see ''[[prostate carcinoma]]'' | |||
}} | |||
'''Sarcomatoid carcinoma of the prostate''', also '''sarcomatoid prostatic carcinoma''', is a rare subtype of [[prostatic carcinoma]] with histomorphologic features suggestive of a sarcoma, and a poor prognosis. | |||
==General== | ==General== | ||
*Rare. | *Rare.<ref name=pmid17001164>{{Cite journal | last1 = Hansel | first1 = DE. | last2 = Epstein | first2 = JI. | title = Sarcomatoid carcinoma of the prostate: a study of 42 cases. | journal = Am J Surg Pathol | volume = 30 | issue = 10 | pages = 1316-21 | month = Oct | year = 2006 | doi = 10.1097/01.pas.0000209838.92842.bf | PMID = 17001164 }}</ref> | ||
*Poor prognosis - estimated 20% mortality at one year.<ref name=pmid17001164/> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_GUP80>{{Ref GUP|77 & 80}}</ref> | Features:<ref name=Ref_GUP80>{{Ref GUP|77 & 80}}</ref> | ||
* | *Typically a biphasic tumour: | ||
*#Spindle cells (sarcomatous component). | *#Spindle cells (sarcomatous component). | ||
*#*May include components of: [[osteosarcoma]], [[chondrosarcoma]] and/or [[rhabdomyosarcoma]]. | *#*May include components of: [[osteosarcoma]], [[chondrosarcoma]] and/or [[rhabdomyosarcoma]]. | ||
*# | *#Epithelial (glandular) component (like conventional prostate carcinoma). | ||
*#*May be absent. ‡ | |||
Note: | |||
* ‡ The history is should be compelling or the tumour keratin positive, if no epithelial component is present. | |||
DDx: | |||
*[[Sarcomatoid urothelial carcinoma]]. | |||
*[[Sarcoma]], e.g. [[rhabdomyosarcoma]], [[liposarcoma]], [[leiomyosarcoma]]. | |||
===Images=== | |||
Sarcomatoid carcinoma: | |||
<gallery> | |||
Image: Sarcomatoid prostate carcinoma -- low mag.jpg | SPC - low mag. | |||
Image: Sarcomatoid prostate carcinoma -- intermed mag.jpg | SPC - intermed. mag. | |||
Image: Sarcomatoid prostate carcinoma -- high mag.jpg | SPC - high mag. | |||
Image: Sarcomatoid prostate carcinoma -- very high mag.jpg | SPC - very high mag. | |||
Image: Sarcomatoid prostate carcinoma - alt -- intermed mag.jpg | SPC - intermed. mag. | |||
Image: Sarcomatoid prostate carcinoma - alt -- high mag.jpg | SPC - high mag. | |||
Image: Sarcomatoid prostate carcinoma - alt -- very high mag.jpg | SPC - very high mag. | |||
</gallery> | |||
Accompanying (conventional) prostatic carcinoma: | |||
<gallery> | |||
Image: Conventional prostate carcinoma -- intermed mag.jpg | SCP - intermed. mag. | |||
Image: Conventional prostate carcinoma -- high mag.jpg | SCP - intermed. mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||