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[[Image:Ballooning degeneration high mag cropped.jpg|thumb|300px|right|Apoptosis ([[ballooning degeneration]]) in the [[liver]]. [[H&E stain]]. (WC)]] | |||
'''Apoptosis''' is programmed/controlled cell death. It can be physiologic, i.e. normal, or pathologic. | '''Apoptosis''' is programmed/controlled cell death. It can be physiologic, i.e. normal, or pathologic. | ||
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*Embryogenesis. | *Embryogenesis. | ||
*Endometrium - during mentruation.<ref name=pmid8923873>{{Cite journal | last1 = Kokawa | first1 = K. | last2 = Shikone | first2 = T. | last3 = Nakano | first3 = R. | title = Apoptosis in the human uterine endometrium during the menstrual cycle. | journal = J Clin Endocrinol Metab | volume = 81 | issue = 11 | pages = 4144-7 | month = Nov | year = 1996 | doi = | PMID = 8923873 }}</ref> | *Endometrium - during mentruation.<ref name=pmid8923873>{{Cite journal | last1 = Kokawa | first1 = K. | last2 = Shikone | first2 = T. | last3 = Nakano | first3 = R. | title = Apoptosis in the human uterine endometrium during the menstrual cycle. | journal = J Clin Endocrinol Metab | volume = 81 | issue = 11 | pages = 4144-7 | month = Nov | year = 1996 | doi = | PMID = 8923873 }}</ref> | ||
==Pathologic== | |||
*[[Ulcerative colitis]] - apoptosis increased.<ref name=pmid19958058>{{Cite journal | last1 = Seidelin | first1 = JB. | last2 = Nielsen | first2 = OH. | title = Epithelial apoptosis: cause or consequence of ulcerative colitis? | journal = Scand J Gastroenterol | volume = 44 | issue = 12 | pages = 1429-34 | month = | year = 2009 | doi = 10.3109/00365520903301212 | PMID = 19958058 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*Apoptotic bodies (membrane bound cell fragments) - '''key feature'''. | *Apoptotic bodies (membrane bound cell fragments) - '''key feature'''. | ||
*Cell shrinkage. | *Cell shrinkage. | ||
*Cytoplasm usu. eosinophilic (pink). | |||
*Lack of inflammation, i.e. [[neutrophils]]. | *Lack of inflammation, i.e. [[neutrophils]]. | ||
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