Difference between revisions of "Peritumoural lymphocytic response"

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Image:Peritumour lymphocytic response - intermed mag.jpg | PLR - intermed. mag. (WC)
Image:Peritumour lymphocytic response - intermed mag.jpg | PLR - intermed. mag. (WC)
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*[http://ajcp.ascpjournals.org/content/134/3/478/F3.expansion.html Peritumour lymphocytic response in CRC (ascpjournals.org)].<ref name=pmid20716806>{{Cite journal  | last1 = Ross | first1 = JS. | last2 = Torres-Mora | first2 = J. | last3 = Wagle | first3 = N. | last4 = Jennings | first4 = TA. | last5 = Jones | first5 = DM. | title = Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 478-90 | month = Sep | year = 2010 | doi = 10.1309/AJCP2Y8KTDPOAORH | PMID = 20716806 | URL = http://ajcp.ascpjournals.org/content/134/3/478.full}}</ref>  -->


==See also==
==See also==

Revision as of 19:14, 13 December 2015

Peritumoural lymphocytic response. H&E stain.

Peritumoural lymphocytic response is an uncommon finding in colorectal carcinoma that is associated with a better prognosis and microsatellite instability.[1]

It is also known as Crohn's like reaction,[2] Crohn's-like lymphoid reaction and Crohn-like response.[3]

General

Microscopic

There are two sets of criteria (Ueno and Graham). The Ueno criteria have a better inter-rater reproducibility than the older Graham criteria[4] and are less complicated.

Ueno criteria (2013)

Required criteria:[5]

  • Non-MALT lymphoid aggregates (peritumoural) >= 1 mm.

Ignore:

  1. Muscosa-associated lymphoid tissue (MALT) = mucosal lymphoid aggregates, submucosal lymphoid aggregates adjacent to the musuclaris mucosae.
  2. Lymph nodes - these have a (fibrous) capsule.
  3. Irregular shape (not round).

Graham criteria (1990)

Required criteria:[4]

  • Peritumoral:
    1. Lymphoid aggregates with germinal centres focally.
    2. Stellate fibrosis.
    3. No previous clinical and pathologic evidence of Crohn's disease.

Note:

Images

See also

References

  1. 1.0 1.1 Harrison, JC.; Dean, PJ.; el-Zeky, F.; Vander Zwaag, R. (Jan 1995). "Impact of the Crohn's-like lymphoid reaction on staging of right-sided colon cancer: results of multivariate analysis.". Hum Pathol 26 (1): 31-8. PMID 7821914.
  2. Ogino, S.; Nosho, K.; Irahara, N.; Meyerhardt, JA.; Baba, Y.; Shima, K.; Glickman, JN.; Ferrone, CR. et al. (Oct 2009). "Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype.". Clin Cancer Res 15 (20): 6412-20. doi:10.1158/1078-0432.CCR-09-1438. PMID 19825961.
  3. URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/Colon_12protocol_3200.pdf. Accessed on: 14 September 2012.
  4. 4.0 4.1 Graham, DM.; Appelman, HD. (May 1990). "Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator.". Mod Pathol 3 (3): 332-5. PMID 2362940.
  5. Ueno, H.; Hashiguchi, Y.; Shimazaki, H.; Shinto, E.; Kajiwara, Y.; Nakanishi, K.; Kato, K.; Maekawa, K. et al. (Apr 2013). "Objective Criteria for Crohn-like Lymphoid Reaction in Colorectal Cancer.". Am J Clin Pathol 139 (4): 434-41. doi:10.1309/AJCPWHUEFTGBWKE4. PMID 23525613.