Difference between revisions of "Parathyroid hyperplasia"

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#redirect [[Parathyroid_glands#Parathyroid_hyperplasia]]
'''Parathyroid hyperplasia''' is a common cause of [[hyperparathyroidism]] that is often associated with [[chronic renal failure]].


==General==
*Common cause of [[hyperparathyroidism]].
*Usually associated with [[chronic renal failure]].
*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref>
==Gross==
*Classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8|1128}}</ref>
==Microscopic==
Features:<ref name=Ref_PBoD8_1128>{{Ref PBoD8|1128}}</ref>
*Classically have abundant adipose tissue.
*+/-Water-clear cells ("water-clear cell hyperplasia").
Note:
*Generally, it is impossible to discern between [[parathyroid adenoma]]s and [[parathyroid hyperplasia]]s by histology alone.<ref name=Ref_BITFS191>{{Ref BITFS|191}}</ref>
**One requires information of the size of the other glands to make the diagnosis.
DDx:
*[[Parathyroid adenoma]] - classically have a rim of normal parathyroid gland around it.
==Sign out==
<pre>
A. Right Superior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.
B. Right Inferior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.
C. Portion of Left Inferior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.
D. Left Superior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.
</pre>
==See also==
*[[Parathyroid gland]].
*[[Hyperparathyroidism]].
==References==
{{Reflist|1}}
[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Endocrine pathology]]

Revision as of 04:44, 10 December 2015

Parathyroid hyperplasia is a common cause of hyperparathyroidism that is often associated with chronic renal failure.

General

Gross

  • Classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.[2]

Microscopic

Features:[2]

  • Classically have abundant adipose tissue.
  • +/-Water-clear cells ("water-clear cell hyperplasia").

Note:

DDx:

Sign out

A. Right Superior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.

B. Right Inferior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.

C. Portion of Left Inferior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.

D. Left Superior Parathyroid, Excision:
- Parathyroid tissue compatible with hyperplasia.

See also

References

  1. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 29 July 2010.
  2. 2.0 2.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1128. ISBN 978-1416031215.
  3. Taxy, J.; Husain, A; Montag, A. (2009). Biopsy Interpretation: The Frozen Section (1st ed.). Lippincott Williams & Wilkins. pp. 191. ISBN 978-0781767798.