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Parathyroid hyperplasia (view source)
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'''Parathyroid hyperplasia''' is a common cause of [[hyperparathyroidism]] that is often associated with [[chronic renal failure]]. | |||
==General== | |||
*Common cause of [[hyperparathyroidism]]. | |||
*Usually associated with [[chronic renal failure]]. | |||
*May be syndromic - chief cell hyperplasia - associated with [[MEN 1]], [[MEN 2A]].<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 29 July 2010.</ref> | |||
==Gross== | |||
*Classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.<ref name=Ref_PBoD8_1128>{{Ref PBoD8|1128}}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD8_1128>{{Ref PBoD8|1128}}</ref> | |||
*Classically have abundant adipose tissue. | |||
*+/-Water-clear cells ("water-clear cell hyperplasia"). | |||
Note: | |||
*Generally, it is impossible to discern between [[parathyroid adenoma]]s and [[parathyroid hyperplasia]]s by histology alone.<ref name=Ref_BITFS191>{{Ref BITFS|191}}</ref> | |||
**One requires information of the size of the other glands to make the diagnosis. | |||
DDx: | |||
*[[Parathyroid adenoma]] - classically have a rim of normal parathyroid gland around it. | |||
==Sign out== | |||
<pre> | |||
A. Right Superior Parathyroid, Excision: | |||
- Parathyroid tissue compatible with hyperplasia. | |||
B. Right Inferior Parathyroid, Excision: | |||
- Parathyroid tissue compatible with hyperplasia. | |||
C. Portion of Left Inferior Parathyroid, Excision: | |||
- Parathyroid tissue compatible with hyperplasia. | |||
D. Left Superior Parathyroid, Excision: | |||
- Parathyroid tissue compatible with hyperplasia. | |||
</pre> | |||
==See also== | |||
*[[Parathyroid gland]]. | |||
*[[Hyperparathyroidism]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Endocrine pathology]] | |||