Ovarian fibroma: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Ovarian_fibroma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Ovarian fibroma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = [[spindle cell]]s with a central nucleus and no nuclear atypia; | |||
patternless pattern (not fascicular, not [[herring bone]]), +/-calcification | |||
| Subtypes = | |||
| LMDDx = [[thecoma]], [[leiomyoma]], [[fibrosarcoma]], metastatic [[metaplastic carcinoma]], [[endometriosis]] with fibrosis | |||
| Stains = | |||
| IHC = inhibin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = solid white mass, usu. well-circumscribed | |||
| Grossing = | |||
| Site = [[ovary]] - see ''[[ovarian tumours]]'' | |||
| Assdx = | |||
| Syndromes = [[Meigs syndrome]], [[nevoid basal cell carcinoma syndrome]] (esp. if calcified) | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other ovarian tumours - esp. solid ones | |||
| Tx = | |||
}} | |||
'''Ovarian fibroma''' is a benign [[ovarian tumour]]. | '''Ovarian fibroma''' is a benign [[ovarian tumour]]. | ||
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==Gross== | ==Gross== | ||
Features: | Features: | ||
*Solid white mass, | *Solid white mass, usually well-circumscribed.<ref name=Ref_AoGP398>{{Ref AoGP|398}}</ref> | ||
Note: | Note: | ||
| Line 21: | Line 53: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref>URL: [http://www.pathologyoutlines.com/ovarytumor.html#fibroma http://www.pathologyoutlines.com/ovarytumor.html#fibroma]. Accessed on: 7 May 2012.</ref><ref name=pmid16810055/> | Features:<ref>URL: [http://www.pathologyoutlines.com/ovarytumor.html#fibroma http://www.pathologyoutlines.com/ovarytumor.html#fibroma]. Accessed on: 7 May 2012.</ref><ref name=pmid16810055>{{Cite journal | last1 = Roth | first1 = LM. | title = Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. | journal = Int J Gynecol Pathol | volume = 25 | issue = 3 | pages = 199-215 | month = Jul | year = 2006 | doi = 10.1097/01.pgp.0000192271.22289.e6 | PMID = 16810055 }}</ref> | ||
*[[Spindle cell]]s with central nucleus and no nuclear atypia. | *[[Spindle cell]]s with central nucleus and no nuclear atypia. | ||
*Patternless pattern ([[AKA]] storiform pattern) - not fascicular, not herring bone. | *Patternless pattern ([[AKA]] storiform pattern) - not fascicular, not herring bone. | ||
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DDx: | DDx: | ||
*[[Thecoma]] - lipid. | *[[Thecoma]] - lipid. | ||
*[[Leiomyoma]] - fascicular architecture, rare in the ovary. | *[[Leiomyoma]] - fascicular architecture, rare in the ovary.<ref name=pmid24761396>{{Cite journal | last1 = Rajabi | first1 = P. | last2 = Hani | first2 = M. | last3 = Bagheri | first3 = M. | last4 = Mirzadeh | first4 = F. | title = Large ovarian leiomyoma in young woman. | journal = Adv Biomed Res | volume = 3 | issue = | pages = 88 | month = | year = 2014 | doi = 10.4103/2277-9175.128001 | PMID = 24761396 }}</ref> | ||
*[[Fibrosarcoma]] - nuclear atypia, classically herring bone pattern, very rare. | *[[Fibrosarcoma]] - nuclear atypia, classically herring bone pattern, very rare. | ||
*Metastatic [[metaplastic carcinoma]] - nuclear atypia, rare. | *Metastatic [[metaplastic carcinoma]] - nuclear atypia, rare. | ||