Difference between revisions of "Urothelial carcinoma-like prostatic carcinoma"
Jump to navigation
Jump to search
| Line 6: | Line 6: | ||
*Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap. | *Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap. | ||
*Relative proximity of the [[urinary bladder]] and [[prostate]] results in clinical scenarios where the primary is not readily apparent. | *Relative proximity of the [[urinary bladder]] and [[prostate]] results in clinical scenarios where the primary is not readily apparent. | ||
==Gross== | |||
Classic tumour locations: | |||
*Bladder neck. | |||
*Trigone/base of bladder. | |||
*Prostatic urethra. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 05:24, 21 October 2015
Urothelial carcinoma-like prostatic carcinoma is a prostatic carcinoma that histologically mimics urothelial carcinoma.
It is not a formally recognized type of prostate cancer.
General
- Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
- Relative proximity of the urinary bladder and prostate results in clinical scenarios where the primary is not readily apparent.
Gross
Classic tumour locations:
- Bladder neck.
- Trigone/base of bladder.
- Prostatic urethra.
Microscopic
Features:
- Large epithelioid cells with prominent nucleoli.
- +/-Papillary structures (pseudopapillae).[1]
- +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.
DDx:
- Urothelial carcinoma.
- Collision tumour consisting of urothelial carcinoma and prostatic carcinoma.
- Other carcinomas.
Images
UCLPC - very low mag.
UCLPC - low mag.
UCLPC - low mag.
UCLPC - intermed. mag.
UCLPC - intermed. mag.
UCLPC - high mag.
UCLPC - high mag.
UCLPC - very high mag.
UCLPC - very high mag.
PC - intermed. mag.
PC - high mag.
IHC
Features:[1]
- GATA3 -ve.
- NKX3.1 +ve.
Images
UCLPC - NKX3.1 - intermed. mag.
UCLPC - AMACR-CK5/6 - very low mag.
UCLPC - AMACR-CK5/6 - intermed. mag.
UCLPC - GATA3 - intermed. mag.
Urothelium - GATA3 - high mag.
