Difference between revisions of "Urothelial carcinoma-like prostatic carcinoma"

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Features:
Features:
*Large epithelioid cells with prominent nucleoli.
*Large epithelioid cells with prominent nucleoli.
*+/-Papillary structures (pseudopapillae).
*+/-Papillary structures (pseudopapillae).<ref name=pmid24503758/>
*+/-Features suggestive of prostatic carcinoma - cribriforming glands ''or'' poorly formed glandular structures.
*+/-Features suggestive of prostatic carcinoma - cribriforming glands ''or'' poorly formed glandular structures.


Line 16: Line 16:
**[[High grade papillary urothelial carcinoma]].
**[[High grade papillary urothelial carcinoma]].
*[[Collision tumour]] consisting of [[urothelial carcinoma]] and [[prostatic carcinoma]].
*[[Collision tumour]] consisting of [[urothelial carcinoma]] and [[prostatic carcinoma]].
*Other [[carcinoma]]s.


===Images===
===Images===

Revision as of 05:17, 21 October 2015

Urothelial carcinoma-like prostatic carcinoma is a prostatic carcinoma that histologically mimics urothelial carcinoma.

It is not a formally recognized type of prostate cancer.

General

  • Uncommon.

Microscopic

Features:

  • Large epithelioid cells with prominent nucleoli.
  • +/-Papillary structures (pseudopapillae).[1]
  • +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.

DDx:

Images

  • UCLPC - very low mag.

  • UCLPC - low mag.

  • UCLPC - low mag.

  • UCLPC - intermed. mag.

  • UCLPC - intermed. mag.

  • UCLPC - high mag.

  • UCLPC - high mag.

  • UCLPC - very high mag.

  • UCLPC - very high mag.

  • PC - intermed. mag.

  • PC - high mag.

IHC

Features:[1]

  • GATA3 -ve.
  • NKX3.1 +ve.

Images

  • UCLPC - NKX3.1 - intermed. mag.

  • UCLPC - AMACR-CK5/6 - very low mag.

  • UCLPC - AMACR-CK5/6 - intermed. mag.

  • UCLPC - GATA3 - intermed. mag.

  • Urothelium - GATA3 - high mag.

See also

References

  1. ↑ 1.0 1.1 Gordetsky, J.; Epstein, JI. (Jul 2014). "Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall.". Am J Surg Pathol 38 (7): 941-5. doi:10.1097/PAS.0000000000000178. PMID 24503758.
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